Figure 8
From: Nucleosome organization in the vicinity of transcription factor binding sites in the human genome
Three nucleosome occupancy clusters around all TF binding sites and expression levels of target genes for each of the clusters. (A) Three nucleosome occupancy clusters identified using CAGT in the GM12878 cell line. The first three panels were traditional aggregate plots of the nucleosome occupancy signals for all TFBSs, TFBSs with high nucleosome signals and TFBSs with low nucleosome signals. The rest of the panels exhibited three nucleosome occupancy patterns averaged over the sites in each of the clusters. (B) Expression levels of target genes for each of the clusters in the GM12878 cell line. Target genes were divided into four categories based on their expression levels: very lowly, lowly, medium and highly expressed genes. The y axis indicated the proportions of target genes that fell into each category. (C) Three nucleosome occupancy clusters identified using CAGT in the K562 cell line. (D) Expression levels of target genes for each of the clusters in the K562 cell line.