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Figure 1 | BMC Genomics

Figure 1

From: Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha

Figure 1

Genome-wide analysis of ZNF217chromatin occupancy. (A) Distribution of ZNF217 binding sites relative to the nearest annotated TSS. (B) Heatmaps depict H3K4me3, H3K27ac, H3K27me3, and H3K9me3 ChIP-Seq signals at regions spanning ZNF217 binding sites (±2 kb) in MCF7 cells organized according to their chromatin status: cluster I and cluster II. Active K4me3-only (cluster I) sites are predominately promoters, while K4me1 and K27ac sites (cluster II) are primarily enriched for distal regions. (C) Average p300 (black), H3K4me1 (red), and H3K27me3 (orange) ChIP-seq enrichment profiles around central position of ZNF217 binding sites.

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