Figure 7

ZNF217 expression is prognostic of reduced survival in patients with ER⁺and Luminal A breast tumors. ZNF217 gene expression was analyzed using the Kaplan Meier-Plotter, an online survival analysis tool to analyze gene expression with breast cancer prognosis using microarray data from 1,809 patients [38]. High ZNF217 expression affects Overall Survival in Luminal A but not Luminal B ER⁺ breast cancer patients (any systemic anti-hormonal therapy treatment and/or chemotherapy). The prognostic value of high ZNF217 expression (median cutoff) was compared to the patient cohort with low ZNF217 expression in (A) All ER⁺ patients (n = 823), p = 0.03. (B) Luminal A (n = 504), p = 0.035 (C) Luminal B (n = 319), p = 0.96. (D) High ZNF217 correlates with worse survival in ER⁺ patients treated with any endocrine therapy (but not chemotherapy). The prognostic value of high ZNF217 (n = 78) expression (upper quartile) was compared to the patient cohort with low ZNF217 expression (n = 236), p = 0.01.