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Table 1 Gene ontology analysis of CG-1521-sensitive strains using DAVID bioinformatics

From: High throughput screening identifies modulators of histone deacetylase inhibitors

Gene ontology analysis: sensitive strains

Category (GO-FAT)

p-value

Corrected

p-value

Represented strains

Chromosome Organization

GO:0051276

4.5E-5

1.5E-3

49

   Chromatin Organization

GO:0006325

1.2E-8

7.1E-6

41

   Chromatin Modification

GO:0016568

1.4E-7

4.3E-5

35

   Histone Modification

GO:0016570

6.5E-7

1.3E-4

23

   Histone Exchange

GO:0043486

3.1E-4

7.0E-3

6

Transcription

GO:0006350

1.7E-6

2.1E-4

69

   Regulation of Transcription

GO:0045449

7.0E-8

2.8E-5

82

   Positive Regulation of Transcription

GO:0045941

6.1E-6

3.8E-4

30

   Negative Regulation of Transcription

GO:0016481

1.1E-5

5.6E-4

32

   Regulation of Transcription from RNA Pol II Promoter

GO:0006357

5.2E-3

6.9E-2

31

SAGA Complex

GO:0000124

6.9E-6

6.2E-4

10

Swr1 Complex

GO:0000812

1.8E-3

2.6E-2

6

Rpd3L Complex

GO:0033698

1.8E-3

2.6E-2

6

  1. Four hundred and seven sensitive strains were identified. Reported p values have been corrected using the methods described by Benjamini and Hochberg. The GO FAT database, developed as part of DAVID, removes very broad GO terms and comprises more specific terms [28, 29].