Table 1 Summary of 53 eQTL datasets, their origins and original reported parameters
From: Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs
Author (PMID) | Tissues (Sample size) | cis analysis | trans analysis | Imputation (SNPs tested)* | Genes analyzed |
|---|---|---|---|---|---|
Brain tissues | |||||
Emilsson (23622250) † | DLPFC, VC, CR versus: All samples (n = 742), Alzheimer’s (n = 376), Huntington’s (n = 193)†, Normal (n = 173) | <1 Mb | Yes (diff. chr) | No (838,958) | 39,579 |
Kleinman (22031444) | PFC_EA + AA + others (n = 269), PFC_AA (n = 147), PFC_EA (n = 112) | n/a | Yes (all) | No (625,439) | 30,176 |
Liu (20351726) | PFC (n = 127) | <1 Mb | Yes | No (366,140) | 6,968 |
Webster (19361613) | Cortex (n = 364), Cortex:Alzh (n = 176) | <1 Mb | Yes (≥1 Mb) | No (502,627) | 24,357 |
Myers (17982457) | Cortex (n = 193) | <1 Mb | Yes (≥1 Mb) | No (366,140) | 14,078 |
Heinzen (19222302) | Cortex (n = 93) | <100 kb | No | No (~550,000) | ~22,000 |
Gibbs (20485568) | Temporal cortex (n = 144), Frontal cortex (n = 143), Cerebellum (n = 143), Pons (n = 142) | <1 Mb | Yes | Yes (~1,655,958) | ~9,372|| |
Blood tissues/cells | |||||
Zeller (20502693) | Monocytes (n = 1,490) | <1 Mb | Yes (≥1 Mb) | No (675,350) | 12,808 |
Fehrmann (21829388) | Whole peripheral blood (n = 1,469) | ≤250 kb | Yes (>5 Mb) | No (290,211) | 19,609 |
Goring (17873875) | Lymphocytes (n = 1,240) | ≤1 Mb | Yes | No (~500,000) | 18,519 |
Dixon (17873877) | LCL (n ~ 400) | <100 kb | Yes (diff. chr) | No (408,273) | 20,599 |
Stranger (17873874) | LCL (n = 210) | ≤1 Mb | Yes (>1 Mb) | Yes (2.2 million) | 13,643 |
Murphy (20833654) | CD4 + lymph (n = 200) | <50 kb | No | No (516,512) | 19,904 |
Idaghdour (19966804) | Leukocytes (n = 194) | <50 kb | Yes (diff. chr) | No (516,972) | 16,738 |
Emilsson (18344981) | Blood (n = 150) | <1 Mb | Yes (≥1 Mb) | No (317,503) | 20,210 |
Heap (19128478) | PaxGene whole blood (n = 110) | <250 kb | No | No (257,013) | 19,867 |
Grundberg (19654370) | Osteoblasts (n = 95) | <250 kb | Yes (diff. chr) | No (383,547) | 18,144 |
Dimas (19644074) | Tcells (n = 85), Fibroblasts (n = 85), LCL (n = 85) | <1 Mb | No | No (394,651) | 17,945 |
Heinzen (19222302) | PBMC (n = 80) | <100 kb | No | No (~550,000) | ~22,000 |
Other tissues/cells | |||||
Greenawalt (21602305) | Liver (n = 651), Subcutaneous Adipose (n = 701), Omentum (n = 848), Stomach (n = 118) | <1 Mb | Yes (>1 Mb) | No (~650,000) | 39,303 |
Schadt (18462017) | Liver (n = 427) | <1 Mb | Yes (≥1 Mb) | No (782,476) | 34,266 |
Innocenti (21637794) | Liver (n = 206), Liver (n = 60) | <250 kb | Yes‡ | HapMap (rel.27) | 14,703|| |
Schroder (22006096) | Liver (n = 149) | <1 Mb | Yes (>1 Mb) | No (299,352) | 15,439 |
Kim † | Kidney (cortex) (n = 81) | <1 Mb | No | No (906,600) | 44,692 |
Emilsson † | Peripheral artery plaque (n = 202) | <1 Mb | Yes (>1 Mb) | No (224,698) | 37,582 |
Emilsson (18344981) | Subcutaneous Adipose (n = 150) | <1 Mb | Yes (≥1 Mb) | No (317,503) | 20,210 |
Ding (21129726) | Normal Skin (n = 57), Psoriasis Lesional Skin (n = 53), Psoriasis UninvolvedSkin (n = 53) | <1 Mb | No | HapMap(rel.21) | ~54,000 |
Kompass (21226949) | Endometrial Tumor (n = 52) | 5 Mb | Yes (>5 Mb) | No (68,523) | 8,543 |