Figure 1

In silico predictions of transcriptional regulatory motifs within gene sets defined from cardiac remodelling transcriptome dynamics. PWM matrices logos are provided in Additional file 1: Figure S1. The temporal expression pattern of the 13 co-expressed gene sets are shown (as defined in [16]; y axis: expression level, x axis: time). Cardiac expression dynamics was analyzed at 21, 24, 27, 30, 33, 36, 42 and 48 hours APF. The PWMs that rank corresponding gene sets above the automatic enrichment score (ES) threshold are displayed, together with their enrichment score and IUPAC sequence (PWMs converted to IUPAC sequence with RSATools “convert matrix” using Drosophila melanogaster as background model [18]). Color code corresponds to stamp clustering of all retrieved PWM across all clusters. Blue: Nuclear receptor R type motifs; green: bZIP motifs; purple: Mef2 like motifs; Pale purple: GATA-like motifs. Note that no PWMs were recovered above the automatic threshold in cluster 1 and 7.