Comparative analysis of the complete genome of KPC-2-producing Klebsiella pneumoniae Kp13 reveals remarkable genome plasticity and a wide repertoire of virulence and resistance mechanisms

Table 1 Main features of the K. pneumoniae Kp13 genome compared to related bacteria

Organism	Size (bp)	G + C content (%)	No. of CDSs^‡	Mean CDS size (bp)	Coding density (%)	No. of tRNAs	Reference
K. pneumoniae Kp13
Chromosome	5,307,003	57.5	5,288	896	89.3	86	This study
Plasmids
pKP13a	2,459	49.2	3	553	67.5	0
pKP13b	3,223	56.3	5	505	78.4	0
pKP13c	5,065	43.8	9	350	62.3	0
pKP13d	45,574	46.0	63	590	81.6	0
pKP13e	81,071	51.1	108	636	84.8	0
pKP13f	295,493	47.9	365	682	84.2	0
K. pneumoniae NTUH-K2044
Chromosome	5,248,520	57.7	5,130	939	89.4	86	[3]
Plasmids
pK2044	224,152	50.2	270	696	83.4	0
K. pneumoniae MGH 78578
Chromosome	5,315,120	57.5	4,776	958	86.1	86	Washington University
Plasmids
pKPN3	175,879	51.7	178	756	76.5	0
pKPN4	107,576	53.4	123	726	83.1	0
pKPN5	88,582	53.8	98	694	76.8	0
pKPN6	4,259	41.4	5	551	64.7	0
pKPN7	3,478	45.7	5	343	49.3	0
K. pneumoniae 342
Chromosome	5,641,239	57.3	5,425	915	88.0	88	[4]
Plasmids
pKP187	187,922	47.2	230	608	74.5	0
pKP91	91,096	51.1	113	635	78.8	0

^‡Number of CDSs according to the submitted GenBank flatfile downloaded from NCBI for each studied genome.

ISSN: 1471-2164