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Table 4 Drug-related efflux pumps identified in compared K. pneumoniae

From: Comparative analysis of the complete genome of KPC-2-producing Klebsiella pneumoniae Kp13 reveals remarkable genome plasticity and a wide repertoire of virulence and resistance mechanisms

System CDS Resistance profileΩ Presence in
    Kp13 NTUH-K2044 MGH 78578 342
RND family       
AcrAB KP03628 AC, BL, BS, CM, CV, EB, FA, FQ, ML, NO, OS, RF, SDS, TX + + + +
AcrD KP03833 AG, DC, FU, NO + + + +
KexD KP05076 EM, EB, NO, RD, TPP + +
MdtABC KP03148 BS, DC, NO + + + +
OqxAB KP02440 CM, FQ, NA, SDS + + + +
MF family       
Bcr KP04395 BI, STZ + + + +
EmrAB KP31576 CCC, NA, TCS, TLM + + + +
Fsr KP03612 FM + + + +
MdfA (KdeA) KP04269 AG, BENZ, CM, EB, FQ, RF, TC + + + +
MdtG KP04943 DC, FOM + + + +
MdtH KP04933 ENX (FQ), NFX + + + +
MdtL KP32205 CM + + + +
SmvA KP04515 CV, EB + + + +
SMR family       
EmrE KP32244 AC, CV, EB +
SugE KP00509 BENZ, EB + + + +
MATE family       
MdtK KP05135 AC, NFX + + + +
ABC family       
MacAB KP04225 ML + + + +
MdlAB KP03663 ? + + + +
  1. ∆, in the case where the pump is encoded by multiple CDSs, the ID corresponds to one of the adjacent CDSs. Ω, based in the literature found for each system. Substrate nomenclature adapted from [54]: AC, acriflavine; AG, aminoglycosides; BI, bicyclomycin; BL, beta-lactams; BS, bile salts; BENZ, benzalkonium chloride; CCC, carbonyl cyanide chlorophenylhydrazone; CM, chloramphenicol; CV, crystal violet; DC, deoxycholate; EB, ethidium bromide; EM, erythromycin; ENX, enoxacin; FA, fatty acids; FQ, fluoroquinolones; FOM, fosfomycin; FM, fosmidomycin; FU, fusidic acid; ML, macrolides; NA, nalidixic acid; NFX, norfloxacin; NO, novobiocin; OS, organic solvents; RD, rhodamine; RF, rifampicin; SDS, sodium dodecyl sulfate; STZ, sulfathiazole; TC, tetracycline; TCS, tetrachlorosalicylanilide; TLM, thiolactomycin; TPP, tetraphenylphosphonium chloride; TX, Triton X-100; ?, regarded as related to multidrug-resistance, but with an unknown resistance spectrum. *, evaluated by BLASTP against the target genome.