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Figure 2 | BMC Genomics

Figure 2

From: Elucidation of the evolutionary expansion of phosphorylation signaling networks using comparative phosphomotif analysis

Figure 2

Extraction of phosphomotifs with sigmoid-type evolutionary patterns. (A) Conservation rates of phosphomotifs. The top 20 motifs with high conservation index values are listed. (B) Clustering of the evolutionary patterns of the phosphorylation motifs. Motifs where the conservation rates changed >50% between two evolutionarily neighboring species were selected. (C) List of the motifs that acquired phosphosites from a specific species. Bar plots and sequence logos of the motifs from the worm, fly, fish, and dog are listed. (D) Example of sequence conservation in a motif across species. The sequence logos in motif 68 are shown for species ranging from the worm to humans. Abbreviations: hsa (Homo sapiens), ptr (Pan troglodytes), mmu (Mus muscullus), dre (Danio rerio), dme (Drosophila melanogaster), cel (Caenorhabditis elegans), spo (Schizosaccharomyces pombe), and sce (Saccharomyces cerevisae).

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