Skip to main content
Figure 6 | BMC Genomics

Figure 6

From: Elucidation of the evolutionary expansion of phosphorylation signaling networks using comparative phosphomotif analysis

Figure 6

Evolutionary expansion of the core signaling network and acquisition of new cellular functions. (A) Differences in the conservation rates of phosphosites between two evolutionarily neighboring species in each category, including all proteins, spliceosomal proteins, cytoskeletal proteins, and insulin signaling-related proteins. (B) Differences in complexes A, B, and C, and common components of spliceosomal proteins. (C) Core signaling network of the proteins with sigmoid-type phosphomotifs (motifs 55, 56, and 58 for the worm; motifs 82, 93, and 121 for the fly; and motifs 46, 135, 140, 159, and 165 for the fish) and the additional network. Blue, green, and yellow boxes indicate proteins with sigmoid-type motifs in the fish, fly, and worm, respectively. (D) Statistics for the core signaling network and additional network. Random interaction networks were generated 100 times using the same number of proteins with the sigmoid-type phosphomotifs in each genome. Odds ratios were calculated for the additional to core signaling network. The odds ratios in the fly were subjected to a correction of 0.5. P-values were calculated using the Chi-square test.

Back to article page