Figure 7

Evolutionary expansion scenarios for phosphorylation networks. Schematic representations of our strategy for filtering phosphorylation signaling networks (top). The global signaling networks were fractionated into biologically enriched terms and phosphorylation using subnetworks of kinases and their substrates based on their levels of evolutionary conservation, where the network used a column called “evolution” to represent evolutionary pressure and phosphosite conservations were used as a carrier. Schematic representations of the motifs acquired from a specific species and the functions of the kinases that phosphorylated the motifs (bottom). The biological functions related to the phosphomotifs were acquired through evolution, and they developed in a highly complex mannern.