TY - JOUR AU - Thompson-Crispi, Kathleen A. AU - Sargolzaei, Mehdi AU - Ventura, Ricardo AU - Abo-Ismail, Mohammed AU - Miglior, Filippo AU - Schenkel, Flavio AU - Mallard, Bonnie A. PY - 2014 DA - 2014/07/04 TI - A genome-wide association study of immune response traits in Canadian Holstein cattle JO - BMC Genomics SP - 559 VL - 15 IS - 1 AB - Breeding for enhanced immune response (IR) has been suggested as a tool to improve inherent animal health. Dairy cows with superior antibody-mediated (AMIR) and cell-mediated immune responses (CMIR) have been demonstrated to have a lower occurrence of many diseases including mastitis. Adaptive immune response traits are heritable, and it is, therefore, possible to breed for improved IR, decreasing the occurrence of disease. The objective of this study was to perform genome-wide association studies to determine differences in genetic profiles among Holstein cows classified as High or Low for AMIR and CMIR. From a total of 680 cows with immune response phenotypes, 163 cows for AMIR (81 High and 82 Low) and 140 for CMIR (75 High and 65 Low) were selectively genotyped using the Illumina Bovine SNP50 BeadChip. Results were validated using an unrelated population of 164 Holstein bulls IR phenotyped for AMIR and 146 for CMIR. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-15-559 DO - 10.1186/1471-2164-15-559 ID - Thompson-Crispi2014 ER -