Table 3 Canonical pathway analyses
Up-regulated | p-value | |
|---|---|---|
Mah VI101 compared to uninfected | TNFR2 signaling | 6.3E-14 |
Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis | 5.0E-11 | |
Death receptor signaling | 5.0E-11 | |
Regulation of cytokine production in macrophages and Th cells by IL-17A and IL-17 F | 6.3E-11 | |
Role of IL-17A in arthritis | 1.9E-10 | |
TNFR1 signaling | 2.8E-10 | |
TREM1 signaling | 7.6E-10 | |
Regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17 F | 1.4E-09 | |
Hepatic fibrosis/Hepatic stellate cell activation | 1.7E-09 | |
IL-6 signaling | 1.9E-09 | |
Mah 1655 compared to uninfected | TNFR2 signaling | 6.3E-12 |
4-1BB signaling in T lymphocytes | 7.2E-10 | |
TNFR1 signaling | 1.1E-09 | |
Small cell lung cancer signaling | 2.9E-09 | |
Role of IL-17A in arthritis | 4.0E-09 | |
Death receptor signaling | 7.6E-09 | |
Induction of apoptosis by HIV1 | 8.9E-09 | |
iNOS signaling | 1.4E-08 | |
Type I diabetes mellitus signaling | 1.5E-08 | |
Regulation of cytokine production in macrophages and Th cells by IL-17A and IL-17 F | 1.9E-08 | |
Maa 1794 compared to uninfected | Death receptor signaling | 1.0E-13 |
TNFR2 signaling | 1.0E-12 | |
Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis | 2.5E-11 | |
Small cell lung cancer signaling | 6.3E-11 | |
Role of IL-17 F in allergic inflammatory airway diseases | 1.4E-10 | |
TWEAK signaling | 3.0E-10 | |
Role of IL-17A in arthritis | 3.7E-10 | |
TNFR1 signaling | 4.1E-10 | |
Regulation of cytokine production in macrophages and Th cells by IL-17A and IL-17 F | 5.1E-10 | |
IL-17A Signaling in fibroblasts | 7.1E-10 | |
Down regulated | p-value | |
Mah VI101 compared to uninfected | Role of CHK proteins in cell cycle checkpoint control | 1.2E-04 |
Tetrapyrrole biosynthesis II | 1.9E-04 | |
Galactose degradation I (Leloir pathway) | 1.9E-04 | |
Mismatch repair in Eukaryotes | 7.8E-04 | |
Heparan sulfate biosynthesis | 8.1E-04 | |
Role of BRCA1 in DNA damage response | 1.2E-03 | |
Heme biosynthesis II | 1.5E-03 | |
Glycine betaine degradation | 2.1E-03 | |
Coenzyme A biosynthesis | 2.2E-03 | |
L-serine degradation | 2.2E-03 | |
Mah 1655 compared to uninfected | Colorectal cancer metastasis signaling | 4.4E-04 |
Hereditary breast cancer signaling | 1.3E-03 | |
Role of BRCA1 in DNA damage response | 1.9E-03 | |
IL-12 signaling and production in macrophages | 2.2E-03 | |
Sulfite oxidation IV | 4.2E-03 | |
Antiproliferative role of TOB in T cell signaling | 5.1E-03 | |
Dendritic cell maturation | 6.0E-03 | |
Role of NFAT in cardiac hypertrophy | 6.5E-03 | |
HMGB1 signaling | 6.6E-03 | |
Superpathway of inositol phosphate compounds | 6.9E-03 | |
Maa 1794 compared to uninfected | Mismatch repair in Eukaryotes | 6.3E-07 |
Role of BRCA1 in DNA damage response | 2.9E-06 | |
CHK proteins in cell cycle checkpoint control | 5.6E-06 | |
CTLA4 signaling in cytotoxic T lymphocytes | 7.9E-06 | |
Hereditary breast cancer signaling | 1.5E-05 | |
Growth hormone signaling | 1.7E-05 | |
Molecular mechanisms of cancer | 1.7E-05 | |
ERK5 signaling | 2.7E-05 | |
Production of NO amd ROS in macrophages | 3.8E-05 | |
B cell receptor signaling | 1.3E-04 |