Skip to main content

Table 4 Upstream regulator analyses

From: Intracellular growth of Mycobacterium avium subspecies and global transcriptional responses in human macrophages after infection

 

Upstream regulator

Activation z-score

p-value of overlap

Mah VI101 compared to uninfected

TNF

12.15

1.40E-76

 

NFkB (complex)

9.02

1.14E-60

 

IL1B

9.32

9.77E-58

 

CD40LG

6.34

2.80E-56

 

TREM1

2.56

2.45E-49

 

IFNG

7.68

2.73E-42

 

RELA

6.59

3.37E-42

 

TNFSF11

6.16

5.99E-41

 

NFKBIA

4.12

8.41E-40

 

IKBKB

5.41

2.25E-35

Mah 1655 compared to uninfected

TNF

8.45

2.79E-58

 

NFkB (complex)

6.45

1.57E-42

 

CD40LG

4.03

5.71E-39

 

IL1B

6.52

8.67E-39

 

IL1A

4.97

1.08E-27

 

TNFSF11

4.30

1.12E-27

 

RELA

5.07

4.74E-27

 

IFNG

5.50

1.72E-26

 

NFKBIA

2.86

2.75E-26

 

TREM1

2.18

2.80E-26

Maa 1794 compared to uninfected

TNF

12.36

6.80E-70

 

NFkB (complex)

9.52

6.86E-63

 

CD40LG

6.40

2.02E-55

 

IL1B

9.70

7.41E-52

 

IFNG

8.72

8.88E-44

 

NFKBIA

3.01

1.96E-39

 

RELA

6.92

2.09E-37

 

TNFSF11

6.55

3.60E-37

 

TLR4

6.58

5.10E-36

 

IL1A

7.19

7.30E-36

  1. Genes predicted to act as up-stream regulators for the observed responses after infection of human monocyte-derived macrophages with M. avium isolates.
  2. The analysis was done in Ingenuity Systems software. Responses to chemicals/drugs are excluded. The ten top genes are shown.