Figure 5

Further refinement of miRNA selection to identify physiologically important miRNAs during repair. Integrated miRNA and gene (GO term) networks of selected miRNA candidates. (a) At 7 dpi, the network was relatively moderate, with a focus on targeting tissue development. (b) At 15 dpi, an extensive network was involved in pulmonary repair and regeneration mainly by targeting cell cycle functions. It is likely that most miRNAs were down-regulated possibly to facilitate developmental gene expression.