Figure 5

Mevalonate (MVA) and Non- mevalonate (MEP) biosynthetic pathways in Ocimum sps. Enzymes found in this study are colored in blue. Graphs represent the average log2fold change observed in the digital gene expression analysis. Abbreviations: AACT, acetoacetyl-CoA thiolase; ADS, amorpha-4,11-diene synthase; ALDH1, aldehyde dehydrogenase 1; BFS, β-farnesene synthase; CPR, cytochrome P450 reductase; CPS, β-caryophyllene synthase; CYP71AV1, amorphadiene-12-hydroxylase; DBR2, artemisinic aldehyde reductase; ECS, epi-cedrol synthase; FDS, farnesyl diphosphate synthase; GAS, germacrene A synthase; HMGR, 3-hydroxy-3-methyl-glutaryl coenzyme A reductase; HMGS, 3-hydroxy-3-methyl-glutaryl coenzyme A synthase; IDI, isopentenyl diphosphate isomerase; MVK, mevalonate kinase; PMD, diphosphomevalonate decarboxylase; PMK, phosphomevalonate kinase; SMO, squalene monooxygenase; SQS, squalene synthase; CMK, 4-cytidine 5′-diphospho-2-C-methyl-Derythritol kinase; DXR, 1-deoxy-D-xylulose-5-phosphate reductoisomerase; DXS, 1-deoxy-D-xylulose-5-phosphate synthase; GGDS, geranylgeranyl diphosphate synthase; GDS, geranyl diphosphate synthase; HDR, hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase; HDS, hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; IDI, isopentenyl diphosphate isomerase; MCT, 2-C-methyl-D-erythritol-4-(cytidyl-5-diphosphate) transferase; MCS, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (adapted from Olfosson et al. [67]).