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Table 2 GO terms for differentially expressed genes

From: Gene expression profiling of mesenteric lymph nodes from sheep with natural scrapie

Term P value ProbeName FC (C vs NC) FC (PC vs NC) Gene symbol Gene name Citation
Glycoprotein 5.16E-04 A_70_P042906 2.22 1.00 AQP1 Aquaporin 1 (Colton blood group)  
CUST_5666_PI375351158 −2.02 −1.16 AQP4 Aquaporin 4 [10]
A_70_P041077 2.09 1.39 PTGER3 Prostaglandin E receptor 3 (subtype EP3)  
A_70_P030356 1.48 −2.06 SLC11A1 Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1  
A_70_P051037 −2.09 2.85 SLC2A5 Solute carrier family 2 (facilitated glucose/fructose transporter), member 5 [10]
A_70_P036386 −1.29 −2.01 UCHL1* Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)  
Extracellular region 5.37E-04 CUST_2502_PI375351158 2.26 2.76 BMPER BMP binding endothelial regulator  
A_70_P006426 4.26 1.06 FGL1 Fibrinogen-like 1  
A_70_P069571 2.05 1.93 FIBIN Fin bud initiation factor homolog (zebrafish)  
A_70_P038041 1.95 −3.63 HP Haptoglobin [10]
CUST_3439_PI375351158 2.70 1.38 PIGR Polymeric immunoglobulin receptor  
A_70_P035871 1.03 −3.29 SERPINE1* Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1  
A_70_P039451 −1.57 −2.28 SFN Stratifin  
A_70_P050922 2.19 −1.06 VEGFA* Vascular endothelial growth factor A  
Disulfide bond 1.10E-03 CUST_598_PI375351158 2.28 1.33 FABP5 Fatty acid binding protein 5 (psoriasis-associated)  
A_70_P070736 −3.83 −1.06 TXNRD1 Thioredoxin reductase 1  
Cell cycle 1.17E-03 A_70_P058586 −2.85 −1.55 PSMA7* Proteasome (prosome, macropain) subunit, alpha type, 7  
A_70_P057841 −1.61 −2.51 BRCA2 Breast cancer 2, early onset  
A_70_P053686 1.11 −2.01 CCNDBP1 Cyclin D-type binding-protein 1  
A_70_P060136 −1.48 −2.04 CGREF1 Cell growth regulator with EF-hand domain 1  
A_70_P027076 −2.79 −1.28 EID1 EP300 interacting inhibitor of differentiation 1  
A_70_P007666 −2.87 −1.61 KIF2C Kinesin family member 2C  
A_70_P011891 −2.34 −1.29 MND1 Meiotic nuclear divisions 1 homolog (S. cerevisiae)  
A_70_P009551 −2.13 −1.07 NCAPG Non-SMC condensin I complex, subunit G  
A_70_P037556 −2.12 1.01 NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae)  
A_70_P034256 −2.20 1.05 TFDP2 Transcription factor Dp-2 (E2F dimerization partner 2)  
A_70_P061801 −2.01 −1.39 UBE2C Ubiquitin-conjugating enzyme E2C  
Condensed chromosome 1.71E-03 CUST_7895_PI375351158 −2.79 −1.15 HMGB1 High-mobility group box 1  
A_70_P003816 −2.20 −1.67 TEX12 Testis expressed 12  
Alternative splicing 2.04E-03 A_70_P059171 −2.57 −2.17 CLTA Clathrin, light chain (Lca)  
A_70_P033441 1.13 2.27 MEST Mesoderm specific transcript homolog (mouse)  
A_70_P039536 −2.86 −1.34 MX1 Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)  
A_70_P060791 2.25 1.38 PEG3 Paternally expressed 3  
A_70_P015446 −1.52 −2.13 UNC50 Unc-50 homolog (C. elegans)  
Chromosome 2.20E-03 A_70_P065046 −2.68 −1.32 JRKL Jerky homolog-like (mouse)  
A_70_P040916 −2.62 −1.67 ORC1L Origin recognition complex, subunit 1-like (yeast)  
CUST_12205_PI375351158 −2.04 −1.20 TOP2A Topoisomerase (DNA) II alpha 170 kDa [33]
Extracellular matrix 3.15E-03 A_70_P021711 −2.19 −1.69 COL1A1 Collagen, type I, alpha 1 [10, 16]
CUST_11292_PI375351158 2.40 1.12 CRISPLD2 Cysteine-rich secretory protein LCCL domain containing 2  
A_70_P007356 2.20 1.26 DCN Decorin [10, 16]
CUST_7449_PI375351158 1.46 −2.05 DPT Dermatopontin  
A_70_P032476 2.45 −1.35 MFAP5 Microfibrillar associated protein 5 [10]
A_70_P058626 2.27 1.13 VWF Von Willebrand factor  
Signal peptide 3.25E-03 A_70_P064081 2.44 −2.18 CA4 Carbonic anhydrase IV  
A_70_P061221 1.20 −2.43 P4HA1 Prolyl 4-hydroxylase, alpha polypeptide I [10, 11]
A_70_P040831 −2.09 −1.07 SELL Selectin L  
Tumor suppressor 1.47E-02 A_70_P035971 2.05 −1.75 VWA5A Von Willebrand factor A domain containing 5A  
A_70_P026737 3.11 −1.41 WT1 Wilms tumor 1  
A_70_P061691 1.26 2.26 HPGD Hydroxyprostaglandin dehydrogenase 15-(NAD)  
Cytoplasm 1.82E-02 A_70_P016337 −1.78 −2.72 HMMR Hyaluronan-mediated motility receptor (RHAMM)  
CUST_12176_PI375351158 −1.04 −2.92 ACTG2 Actin, gamma 2, smooth muscle, enteric  
A_70_P019656 1.01 3.59 ADH1A Alcohol dehydrogenase 1A (class I), alpha polypeptide  
A_70_P045301 3.70 2.33 BBOX1* Butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1  
A_70_P069971 −2.09 −1.73 CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5  
CUST_5823_PI375351158 1.12 2.07 NIN Ninein (GSK3B interacting protein)  
A_70_P018021 −3.25 −1.15 PAIP2 Poly(A) binding protein interacting protein 2  
A_70_P054126 −2.16 −1.11 PHAX Phosphorylated adaptor for RNA export  
A_70_P044246 1.26 −2.14 RRAGD Ras-related GTP binding D  
A_70_P055106 2.05 1.07 SORBS2 Sorbin and SH3 domain containing 2  
A_70_P025726 −2.39 −1.60 STMN2 Stathmin-like 2  
A_70_P060991 −2.80 1.21 CA3 Carbonic anhydrase III, muscle specific  
Fatty acid metabolism 2.26E-02 CUST_8730_PI375351158 1.06 −2.05 ACSL4 Acyl-CoA synthetase long-chain family member 4  
A_70_P039986 −1.27 2.39 SLC27A2 Solute carrier family 27 (fatty acid transporter), member 2  
Phosphatidic acid metabolic process 2.86E-02 A_70_P039726 −2.50 −1.10 AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)  
A_70_P025121 −3.34 −1.30 PLA2G2A Phospholipase A2, group IIA (platelets, synovial fluid)  
Protein dimerization activity 2.91E-02 CUST_206_PI396851701 2.04 −2.28 FOS v-fos FBJ murine osteosarcoma viral oncogene homolog [10, 11, 33]
CUST_10535_PI375351158 −2.41 −2.41 NFE2L1 Nuclear factor (erythroid-derived 2)-like 1  
Zinc finger, C2H2-type 3.09E-02 CUST_13307_PI375351158 −2.34 −1.26 ATMIN ATM interactor  
A_70_P036056 −2.65 −1.71 KLF6 Kruppel-like factor 6  
A_70_P065371 −2.27 −1.13 ZCCHC6 Zinc finger, CCHC domain containing 6  
A_70_P014286 1.33 2.01 ZNF45 Zinc finger protein 45  
Cytoplasmic membrane-bounded vesicle 3.21E-02 A_70_P062831 −3.71 −1.48 EHD3 EH-domain containing 3  
A_70_P044621 2.27 −1.04 MALL Mal, T-cell differentiation protein-like  
Metal ion transport 3.39E-02 A_70_P030126 −2.36 1.24 CP* Ceruloplasmin (ferroxidase) [10, 16]
CUST_12632_PI375351158 2.28 1.50 KCTD12 Potassium channel tetramerisation domain containing 12  
A_70_P027206 2.15 2.10 SLC30A1 Solute carrier family 30 (zinc transporter), member 1 [10, 11]
A_70_P050456 −2.65 −1.58 SLC38A10 Solute carrier family 38, member 10  
Antimicrobial 5.05E-02 CUST_139_PI396851701 15.26 −1.74 CATHL1 Cathelicidin 1  
CUST_3993_PI375351158 5.96 −1.25 S100A8 S100 calcium binding protein A8 [10]
Apoptosis 5.45E-02 CUST_260_PI396851701 −2.04 −1.55 CARD6 Caspase recruitment domain family, member 6  
A_70_P022526 −2.29 −1.16 OPA1 Optic atrophy 1 (autosomal dominant)  
A_70_P049526 −1.12 −2.70 PERP PERP, TP53 apoptosis effector  
A_70_P069836 −3.14 −1.31 RNF130 Ring finger protein 130  
A_70_P067091 −2.90 −1.55 UBE2Z Ubiquitin-conjugating enzyme E2Z  
Immunoglobulin-like fold 5.55E-02 A_70_P036361 2.06 2.09 CD1E CD1e molecule  
CUST_9656_PI375351158 −2.03 1.11 FGFR2 Fibroblast growth factor receptor 2  
CUST_12141_PI375351158 2.64 −1.00 IGK Ig kappa chain  
A_70_P016986 −2.23 1.16 TRD@ T cell receptor delta locus [11]
Secreted 5.70E-02 A_70_P048761 1.34 −2.27 SPINK5 Serine peptidase inhibitor, Kazal type 5  
CUST_9580_PI375351158 1.13 −2.49 MMRN1 Multimerin 1  
CUST_10101_PI375351158 −1.07 −2.53 NPNT Nephronectin  
A_70_P034356 2.88 1.19 SEMA3G Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G  
A_70_P063891 2.38 −1.22 PCOLCE2 Procollagen C-endopeptidase enhancer 2  
GTP binding 7.49E-02 A_70_P019676 4.33 1.16 ACSM1 Acyl-CoA synthetase medium-chain family member 1 [10]
A_70_P046951 −2.24 −1.02 ARL4C ADP-ribosylation factor-like 4C  
A_70_P008796 −2.06 1.15 DOCK11 Dedicator of cytokinesis 11  
A_70_P000126 −3.63 −1.82 GBP4 Guanylate binding protein 4  
Disulfide bond 7.58E-02 A_70_P018376 2.56 −1.08 FAP Fibroblast activation protein, alpha  
A_70_P041321 −2.15 −2.57 IGHA2 Immunoglobulin heavy constant alpha 2 (A2m marker)  
Structural molecule activity 8.04E-02 A_70_P028306 −2.03 −1.05 LMNB1 Lamin B1  
CUST_13373_PI375351158 −2.15 −1.29 LOC531679 Ribosomal protein 17-like; similar to 60S ribosomal Protein L17 (L23); similar to ribosomal protein L17; similar to Rpl17 protein; similar to mCG3798  
CUST_7057_PI375351158 −2.33 −1.07 LOC789587 Similar to Ribosomal_L22 domain containing protein RGD1359290  
A_70_P031441 −2.43 −1.79 VCL Vinculin [11]
Positive regulation of inflammatory response 9.48E-02 A_70_P058551 8.25 −1.12 FABP4 Fatty acid binding protein 4, adipocyte  
CUST_9779_PI375351158 −1.40 −2.38 IDO1 Indoleamine 2,3-dioxygenase 1  
Other   CUST_13467_PI375351158 1.29 −2.14 FBP2 Fructose-1,6-bisphosphatase 2  
A_70_P055306 2.77 1.50 SLC43A1 Solute carrier family 43, member 1  
A_70_P049406 −1.99 −2.32 EIF5 Eukaryotic translation initiation factor 5 [11]
A_70_P070931 −2.87 −1.18 NUDT19 Nudix (nucleoside diphosphate linked moiety X)-type motif 19  
A_70_P036101 1.22 −3.18 NOP10 NOP10 ribonucleoprotein homolog (yeast) [11]
A_70_P011091 −2.74 −2.01 PFDN2* Prefoldin subunit 2  
A_70_P039656 17.20 −1.52 BAC5 5 kDa bactinecin precursor  
A_70_P061341 −1.03 −2.94 C11ORF10 Chromosome 11 open reading frame 10  
A_70_P061266 2.36 1.03 C5ORF43 Chromosome 5 open reading frame 43  
A_70_P051377 14.99 −1.48 CATHL1B Procyclic dodecapeptide  
A_70_P015101 −2.70 −1.03 CCDC82 Coiled-coil domain containing 82  
A_70_P012541 −1.02 −2.36 CNN1 Calponin 1, basic, smooth muscle  
A_70_P002841 2.03 1.48 EPAS Endothelial PAS domain protein 1  
A_70_P008841 −2.18 −1.23 EPSTI1 Epithelial stromal interaction 1 (breast)  
A_70_P060756 −2.12 1.08 FAM190B KIAA1128  
A_70_P062951 2.05 1.12 FNDC3B Fibronectin type III domain containing 3B [33]
A_70_P051181 2.76 1.28 HSD11K NAD-dependent 11-beta-hydroxysteroid dehydrogenase  
CUST_46_PI396851701 −2.06 −2.15 IGHA Immunoglobulin heavy constant alpha  
A_70_P024671 2.46 1.31 INHBB Inhibin, beta B  
A_70_P033656 −2.34 −1.77 ISG12(A) ISG12(a) protein-like  
A_70_P012537 −2.19 −3.58 LGALS15 Galectin 15  
CUST_3620_PI375351158 −1.58 −2.22 LGALS16 Beta-galactoside-binding lectin  
A_70_P020131 −1.10 −3.84 LGALS9C Lectin, galactoside-binding, soluble, 9C  
CUST_6089_PI375351158 −2.02 −1.71 LOC100140018 Similar to cytochrome P450, family 2, subfamily J  
A_70_P016801 −2.20 −1.48 LOC443321 Lysozyme 2a precursor  
A_70_P026671 −1.91 −2.05 LOC524810 IgM  
A_70_P023026 3.09 1.74 LOC615697 Similar to cytochrome P450  
A_70_P039266 −2.03 −1.83 LOC654331 Pancreatitis-associated protein I [10]
A_70_P039271 −3.94 −7.40 MCP-4 Mast cell proteinase-4  
CUST_11558_PI375351158 2.00 2.23 MGC140754 Hypothetical LOC508613  
CUST_9725_PI375351158 −2.26 −3.77 PLAC8 Placenta-specific 8  
CUST_10114_PI375351158 2.56 1.15 RN18S1 18S ribosomal RNA  
A_70_P030132 −2.40 −1.71 RTP4 Receptor (chemosensory) transporter protein 4 [34]
A_70_P030426 10.95 1.39 SC5 Cathelin-related prepropeptide  
  1. *Genes selected for validation by quantitative RT-PCR.
  2. BLAST results for clones exhibiting significant alterations in gene expression (P ≤ 0.05 and ≥ 2-fold change) in preclinical and clinical stages of natural scrapie. The GO was determined using DAVID Bioinformatics Resources 6.7 (NIAID/NIH, USA), an on-line functional annotation tool. Only genes with a known GO are shown. (C, Clinical; FC, Fold change; NC, Negative control; PC, Preclinical). Previous studies describing altered expression of the differentially expressed genes reported here in the brain and lymphoid tissues of experimentally-infected sheep are cited.