Gene expression profiling of mesenteric lymph nodes from sheep with natural scrapie

BMC Genomics

Table 3 Signaling pathways associated with differentially expressed genes

Term	P value	ProbeName	FC (C vs NC)	FC (PC vs NC)	Gene symbol	Gene name
PPAR signaling pathway	1.88E-02	CUST_598_PI375351158	2.28	1.33	FABP5	Fatty acid binding protein 5 (psoriasis-associated)
		CUST_8730_PI375351158	1.06	−2.05	ACSL4	Acyl-CoA synthetase long-chain family member 4
		A_70_P058551	8.25	−1.12	FABP4	Fatty acid binding protein 4, adipocyte
		A_70_P039986	−1.27	2.39	SLC27A2	Solute carrier family 27 (fatty acid transporter), member 2
ECM-receptor interaction	2.53E-02	A_70_P021711	−2.19	−1.69	COL1A1	Collagen, type I, alpha 1
		A_70_P058626	2.27	1.13	VWF	von Willebrand factor
		A_70_P016337	−1.78	−2.72	HMMR	Hyaluronan-mediated motility receptor (RHAMM)
Focal adhesion	6.73E-02	A_70_P021711	−2.19	−1.69	COL1A1	Collagen, type I, alpha 1
		A_70_P058626	2.27	1.13	VWF	von Willebrand factor
		A_70_P050922	2.19	−1.06	VEGFA	Vascular endothelial growth factor A
		A_70_P031441	−2.43	−1.79	VCL	Vinculin

Signaling pathways with which differentially expressed genes (P ≤ 0.05 and ≥ 2-fold change) are associated were identified by enrichment analysis using the on-line functional annotation (DAVID Bioinformatics Resources 6.7; NIAID/NIH, USA). (C, Clinical; FC, Fold change; NC, Negative control; PC, Preclinical).

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