Table 1 List of driver pathways in each subtype
From: Identification of collaborative driver pathways in breast cancer
Subtype | Driver pathway |
|---|---|
Basal-like | PI3K-Akt signaling; MAPK signaling |
HER2+ | PI3K-Akt signaling; MAPK signaling, Apoptosis; Phosphatidylinositol signaling system; Regulation of actin cytoskeleton; Focal adhesion; T cell receptor signaling; Cholinergic synapse; ErbB signaling; Chemokine signaling; Insulin signaling; TNF signaling; Osteoclast differentiation; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Natural killer cell mediated cytotoxicity |
Luminal-A | PI3K-Akt signaling; Focal adhesion; Regulation of actin cytoskeleton; Chemokine signaling; Jak-STAT signaling; Estrogen signaling |
Luminal-B | PI3K-Akt signaling; Focal adhesion; Apoptosis; ErbB signaling; Estrogen signaling; HIF-1 signaling; mTOR signaling; Jak-STAT signaling; Progesterone-mediated oocyte maturation; Carbohydrate digestion and absorption; Cholinergic synapse; T cell receptor signaling; Insulin signaling; Phosphatidylinositol signaling system; Natural killer cell mediated cytotoxicity |