Figure 5From: Bis-class: a new classification tool of methylation status using bayes classifier and local methylation informationThe GB 16479 locus exhibits qualitatively identical information yet opposite methylation calling under the binomial method. Data are from unpublished methylC-seq experiments of two honey bee individuals from the Yi lab, and are available upon request. All reads mapped to the four CpGs are ‘C’ reads (indicating 100% methylation). However, the binomial method provides a different methylation calls for these two samples. Specifically, the binomial calls all CpGs in the sample A as non-methylated (white dots), and all CpGs in the sample B as methylated (black dots). Bis-Class correctly identifies identical methylation features in the two replicates.Back to article page