Figure 2

Developmental regulation of gene expression. (A) A transcriptional heatmap of standardized gene expression patterns of the 6,586 developmentally regulated genes, ordered according to their regulatory patterns. The colors represent relative gene expression level (see scale). Each row represents a gene and each large column represents a time point, with a figure of corresponding developmental stage on the top. Within the large column, the four small columns represent data from clonal, chimeric, clonal, and chimeric pairs, respectively. The dark red lines divide the genes into three groups: down-regulated, other-regulated, and up-regulated genes. Number of genes in each group is indicated in parenthesis. (B) Venn diagrams compares the numbers of genes that fall into the specific regulatory patterns identified in our study and in a previous RNA sequencing (RNA-Seq) transcriptome study (Parikh et al.[19]). The pink circle represents genes identified by our customized Agilent microarray, and the blue circle represents results from the RNA-Seq study. From top to bottom: down-regulated, other-regulated, and up-regulated genes.