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Figure 1 | BMC Genomics

Figure 1

From: The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression

Figure 1

Generation of a beta cell reporter mouse that faithfully and selectively marks all beta cells. A fusion of histone-2b (H2b) and monomeric cherry (mCherry) was inserted downstream of the long Ins1 promoter fragment (A) to generate a mIns1-H2b-mCherry beta cell reporter mouse that features nuclear expression of mCherry in all beta cells (B). Male (C) and female (D) mIns1-H2b-mCherry mice demonstrate normal glucose control as demonstrated by glucose tolerance test compared to wild type littermates.

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