Comparison of mouse beta and alpha cell transcriptomes based on functional annotation. Establishment and maintenance of alpha and beta cell identity is regulated by a complex interplay of transcription factors (A), whose expression pattern is accurately reflected by our mouse alpha and beta cell transcriptomes. Actual transcription factor expression in beta and alpha cells is represented by a dot plot where each dot represents an individual gene (B). Genes that are significantly enriched (p < 1 × 10-7) in beta or alpha cells are highlighted in red and green, respectively, with genes enriched with p < 1 × 10-50 displayed in bold for emphasis. Ins1, Ins2, and Gcg are marked for reference. See also Additional files 5 and 6.