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Figure 1 | BMC Genomics

Figure 1

From: Systematic permutation testing in GWAS pathway analyses: identification of genetic networks in dilated cardiomyopathy and ulcerative colitis

Figure 1

The two distributions represent the result of the column and row I permutation test approach. The original data set revealed a total of 6,226 significantly associated genes (dashed line). Following permutations of the case–control status (red), a significantly decreased number of genes is discovered to be significant. Following the SNP permutations (row permutations I), a significantly increased number of genes was discovered to be significant. The second row based permutation strategy preserved the number of genes (6,226). The respective gene sets have been used as input for the pathway analysis.

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