Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks

Table 1 Summary of microarray analysis

Time-point Region		P1	P15	P30	P84	Total number of unique DEGs
Cerebral Cortex	Probe set	20	5	15	20	40
Cerebral Cortex	DEG	12↑ 8↓	4↑ 1↓	13↑ 2↓	13↑ 6↓	40
Cerebellum	Probe set	117	53	18	93	201
Cerebellum	DEG	46↑ 66↓	43↑ 1↓	12↑ 4↓	64↑ 23↓	201
Hippocampus	Probe set	28	59	22	81	129
Hippocampus	DEG	22↑ 4↓	48↑ 3↓	20↑ 1↓	69↑ 7↓	129
Total number of unique DEGs		131	80	30	145	(317)

↑ denotes ‘upregulation’, ↓ denotes ‘downregulation’, DEG denotes ‘differentially expressed gene’ and P denotes ‘postnatal day’. The value in parentheses denotes non-redundant unique DEGs based on the spatiotemporal comparison between Ts1Cje and disomic mice.

ISSN: 1471-2164