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Table 2 Summary of spatiotemporal microarray profiling of 41 DEGs found in the triplicated segment of MMU16

From: Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks

Full gene name (Official gene symbol)

Probe set ID

Log2expression of Ts1Cje normalized against disomic littermates

Cerebral cortex

Cerebellum

Hippocampus

P1

P15

P30

P84

P1

P15

P30

P84

P1

P15

P30

P84

RIKEN cDNA 1110004E09Rik gene (1110004E09Rik)

1424315_at

0.72

0.70

0.67

0.73

1.39*

0.91

0.91

0.70

0.61

1.12

0.97

0.83

RIKEN cDNA 2410124H12Rik gene (2410124H12Rik)

1432515_at

0.03

0.09

0.01

0.16

0.07

1.68**

1.51***

2.26***

-0.02

-0.08

0.05

-0.14

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (Atp5o)

1416278_a_at

0.65

0.49

0.70

0.48

0.43

0.67

0.82*

0.54

0.68

0.37

0.48

1.09***

1437164_x_at

0.58

0.71

0.72*

0.64

0.68*

0.74**

0.78**

0.59

0.71*

0.64*

0.74*

0.94***

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (B3galt5)

1450528_at

0.00

0.02

-0.02

0.00

0.02

0.15

-0.01

0.43

-0.02

-0.11

0.15

1.25*

Expressed sequence BF642829 (BF642829)

1435484_at

0.56

0.34

0.68

-0.04

0.91**

0.75*

0.68

0.01

0.59

0.69

0.89**

0.17

Bromodomain and WD repeat domain containing 1 (Brwd1)

1427322_at

0.67

0.45

0.50

0.40

0.32

0.81*

0.84*

0.54

0.78

0.26

0.52

1.11***

1433955_at

0.55

0.53

0.63

0.86*

1.17***

0.81**

0.57

1.01***

0.39

0.70*

0.70*

0.91***

1452322_a_at

0.07

0.62

0.47

0.83*

0.14

0.37

0.22

0.94***

0.67*

0.46

0.68*

0.22

C2 calcium-dependent domain containing 2 (C2cd2)

1436344_at

0.47

0.47

0.38

0.54

0.27

1.87***

0.47

0.74

0.39

0.71

0.91

0.68

1437731_at

0.79

0.30

0.15

0.47

0.59

1.21*

0.18

0.45

0.58

0.32

0.55

0.18

Carbonyl reductase 1 (Cbr1)

1460196_at

0.67

0.48

0.66

0.58

0.71

0.52

0.30

0.72*

0.64

0.95**

0.72

0.74*

Carbonyl reductase 3 (Cbr3)

1427912_at

1.55

1.11

0.82

0.81

1.08

-0.02

0.21

0.79

1.24

2.04*

1.07

0.44

Chromatin assembly factor 1, subunit B (p60) (Chaf1b)

1423877_at

1.15***

0.10

0.00

0.08

0.93***

-0.03

-0.06

0.00

1.51***

0.05

-0.08

-0.11

Crystallin, zeta (quinone reductase)-like 1 (Cryzl1)

1430547_s_at

0.70

0.57

0.76

0.55

0.60

0.70

0.97

0.94*

0.57

0.17

0.37

1.28***

1451473_a_at

0.47

0.61

0.86**

0.67

0.61

0.88***

0.49

0.51

0.57

0.82**

0.85**

0.59*

DnaJ (Hsp40) homolog, subfamily C, member 28 (Dnajc28)

1420542_at

0.36

0.29

0.14

0.18

0.26

0.33

0.21

0.81*

0.28

0.15

0.26

0.23

Downstream neighbor of SON (Donson)

1426739_at

0.76

0.72

0.91**

0.78

0.82*

0.91**

0.75

0.75*

0.81*

0.65

0.63

0.92**

Dopey family member 2 (Dopey2)

1428330_at

0.68*

0.47

0.61

0.45

0.58

0.83**

0.70*

0.59

1.00***

0.68*

0.85**

0.77**

Down syndrome cell adhesion molecule (Dscam)

1441082_at

0.35

0.70

1.13

0.78

0.41

0.36

0.94

0.74

0.40

1.60**

1.13

0.59

1449411_at

0.94

0.83

0.98

1.03

0.69

0.54

0.70

1.22*

0.81

1.52**

0.87

0.86

1458625_at

0.52

0.44

0.74

0.72

0.79

0.11

0.33

0.50

0.72

1.65***

1.39**

0.45

Down syndrome critical region 3 (Dscr3)

1415745_a_at

0.87

0.74

0.66

0.91

0.97*

0.93*

0.87

0.66

0.80

0.89*

1.01*

0.94*

E26 avian leukemia oncogene 2, 3' domain (Ets2)

1416268_at

0.78

0.62

0.81

0.56

0.54

0.87*

0.65

0.80*

0.62

0.45

0.68

0.77

Phosphoribosylglycinamide formyltransferase (Gart)

1416283_at

0.52

0.38

0.92

0.37

0.39

1.17**

0.54

0.93

0.70

0.95

1.20*

0.95

1424436_at

0.41

0.85

0.70

0.98

0.98

1.03*

0.20

1.30***

0.18

0.93

0.69

0.67

High mobility group nucleosomal binding domain 1 (Hmgn1)

1422495_a_at

0.51

0.60

0.59

0.55

0.22

0.96**

0.49

0.68*

0.36

0.16

0.64

0.82**

1438940_x_at

0.39

0.52

0.50

0.67

0.40

0.76*

0.24

0.54

0.39

0.33

0.50

0.36

1455897_x_at

0.44

0.69

0.70

0.95

0.49

1.07**

0.30

0.80

0.40

0.52

0.87

0.58

Hormonally upregulated Neu-associated kinase (Hunk)

1418260_at

0.66

0.66

0.25

0.68

0.41

0.83

0.87

0.64

1.10*

0.52

0.61

1.16**

Interferon (alpha and beta) receptor 1 (Ifnar1)

1442222_at

0.63

0.74

1.05

0.77

0.45

1.12*

0.73

0.68

0.62

0.80

0.80

0.75

1449026_at

0.80

0.80

1.17*

1.29*

0.55

0.67

0.85

1.10*

0.46

1.12*

0.84

0.75

Interferon (alpha and beta) receptor 2 (Ifnar2)

1427691_a_at

0.66

0.52

0.67

0.40

0.55

0.80

0.48

0.58

0.73

1.49*

0.91

0.50

1440169_x_at

0.72

0.92

0.78

0.60

0.89

0.68

0.45

0.34

1.22

1.49*

0.84

0.62

1451462_a_at

0.70

0.90

0.99*

0.98

0.61

0.90*

0.80

0.93*

0.81

0.83

0.92*

1.43***

Interferon gamma receptor 2 (Ifngr2)

1423558_at

0.31

0.39

0.40

0.44

0.67**

0.14

0.17

0.21

0.21

0.45

0.28

0.26

Intersectin 1 (SH3 domain protein 1A) (Itsn1)

1421192_a_at

0.82

0.45

0.90

0.40

0.03

0.94*

1.16**

0.66

1.01*

0.48

0.97*

1.04**

1425899_a_at

0.58

0.61

0.71

0.22

0.35

0.72

1.37

0.90

0.76

-0.54

0.18

1.67*

1435885_s_at

0.56

0.61

0.63

0.66**

0.46

1.18*

0.25

0.50

0.49

0.37

0.97

0.21

1452338_s_at

0.58

0.96

1.42**

1.66

0.44

0.99

0.80

1.30**

0.64

0.25

0.70

0.74

Potassium inwardly-rectifying channel, subfamily J, member 6 (Kcnj6)

1425707_a_at

-0.13

0.24

0.22

0.59

0.18

0.29

0.04

0.31

-0.21

0.57

1.07*

-0.06

Microrchidia 3 (Morc3)

1420091_s_at

0.55

0.81**

0.64

0.66

0.78**

0.84***

0.69*

0.55

0.64*

0.66*

0.78**

0.99***

1452224_at

0.69

0.64

0.68

0.66

0.82

0.99

1.21*

0.52

1.20*

0.51

0.55

1.45**

Mitochondrial ribosomal protein S6 (Mrps6)

1424440_at

0.84**

0.62

0.73

0.35

0.89**

0.70*

0.89**

1.00***

0.77*

0.72*

0.64

0.91**

1447585_s_at

0.93

0.74

0.88

0.74

1.13*

0.88

0.53

0.94

0.61

1.15*

0.91

0.61

PAX3 and PAX7 binding protein 1 (Paxbp1)

1418007_at

0.55

0.66

0.75

0.59

0.55

1.32*

0.59

0.80

0.83

0.15

0.80

0.56

1418008_at

0.46

0.38

0.74

0.62

0.56

1.45*

0.63

0.75

0.92

0.21

0.92

0.86

Phosphatidylinositol glycan anchor biosynthesis, class P (Pigp)

1436038_a_at

0.69*

0.70

0.77*

0.95**

0.77**

0.75**

0.84**

0.82***

0.38

0.54

0.55

1.16***

PR domain containing 15 (Prdm15)

1455459_at

0.41

-0.04

0.47

0.59

0.21

0.37

0.59

0.18

0.44

0.48

0.35

0.95*

Proteasome (prosome, macropain) subunit, alpha type 2 (Psmg1)

1448307_at

0.81*

0.52

0.78

0.97*

0.73

0.99**

0.57

0.88**

0.55

1.04**

0.82*

0.94**

Regulator of calcineurin 1 (Rcan1)

1416600_a_at

0.98*

0.74

0.89

0.43

0.89

0.71

0.70

0.76

0.73

1.10**

0.84

0.68

Receptor-interacting serine-threonine kinase 4 (Ripk4)

1418488_s_at

0.06

0.07

0.00

0.12

0.12

-0.02

0.06

0.02

0.53***

0.02

-0.05

-0.09

Solute carrier family 5 (inositol transporters), member 3 (Slc5a3)

1435484_at

0.56

0.34

0.68

-0.04

0.91***

0.75***

0.68

0.01

0.59

0.69

0.89***

0.17

Small integral membrane protein 11(Smim11)

1417402_at

0.85

0.43

0.64

0.40

0.90*

0.69

0.59

0.59

0.77

0.37

0.68

0.70

Son cell proliferation protein (Son)

1420952_at

0.68

0.69

0.90

0.86

0.36

1.28*

0.71

0.87

0.88

0.54

0.77

0.65

1435862_at

0.64

0.75

0.80

0.63

0.35

1.04**

1.24***

0.78

0.99*

0.20

0.58

1.17**

1437924_at

0.63

0.62

0.79

0.82

0.28

0.96**

0.75

0.67

0.35

0.60

0.65

0.73

Synaptojanin 1 (Synj1)

1436333_a_at

0.67

0.65

0.77

0.84

0.89

0.57

0.74

0.84

0.74

1.38*

0.79

0.72

1454961_at

0.60

0.57

0.65

0.63

0.57

0.43

0.58

0.71*

0.56

0.86**

0.55

0.67

Transmembrane protein 50B (Tmem50b)

1423707_at

0.78**

0.51

0.70*

0.46

0.83**

0.69*

1.07***

0.71**

0.96***

0.76**

0.84**

0.99***

Tetratricopeptide repeat domain 3 (Ttc3)

1416484_at

0.52

0.53

0.68

0.56

0.60

0.39

0.74

0.87*

0.53

0.31

0.26

0.78

1448361_at

0.45

0.45

0.54*

0.43

0.21

0.43

0.46

0.40

0.33

0.63**

0.45

0.46

URB1 ribosome biogenesis 1 homolog (S. cerevisiae) (Urb1)

1454841_at

0.58

0.49

0.77

0.46

0.24

0.16

0.48

0.37

0.98*

0.62

0.76

0.85

Tryptophan rich basic protein (Wrb)

1460446_at

0.62

0.64

0.63

0.74

0.72*

0.90*

0.45

0.67*

0.56

0.85**

0.69

0.70*

  1. *p<0.05, **p<0.01 and ***p<0.001 based on Empirical Bayes t-statistic test.
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BMC Genomics

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