Phylogenetic and domain analyses of C. lunata CX-3 and other fungal polyketide synthases (PKS). (A) A neighbor-joining tree of ketoacyl CoA synthase (KS) domain sequences among fungi. (B) Toxin and melanin related to PKS in other fungi. (C) Domain analysis of the PKS. Domain definitions: KS, ketoacyl CoA synthase; AT, acyltransferase domain; DH, dehydratase domain; ER, enoyl reductase domain; KR, ketoreductase domain; ACP, acyl carrier protein domain; The accessions of other fungi PKSs are shown in the Materials and methods. *CL04686 and CL09981 are up-regulated in virulence-enhanced strain. C. heterostrophus = B. maydis.