TY - JOUR AU - Lange, Vinzenz AU - Böhme, Irina AU - Hofmann, Jan AU - Lang, Kathrin AU - Sauter, Jürgen AU - Schöne, Bianca AU - Paul, Patrick AU - Albrecht, Viviane AU - Andreas, Johanna M. AU - Baier, Daniel M. AU - Nething, Jochen AU - Ehninger, Ulf AU - Schwarzelt, Carmen AU - Pingel, Julia AU - Ehninger, Gerhard AU - Schmidt, Alexander H. PY - 2014 DA - 2014/01/24 TI - Cost-efficient high-throughput HLA typing by MiSeq amplicon sequencing JO - BMC Genomics SP - 63 VL - 15 IS - 1 AB - A close match of the HLA alleles between donor and recipient is an important prerequisite for successful unrelated hematopoietic stem cell transplantation. To increase the chances of finding an unrelated donor, registries recruit many hundred thousands of volunteers each year. Many registries with limited resources have had to find a trade-off between cost and resolution and extent of typing for newly recruited donors in the past. Therefore, we have taken advantage of recent improvements in NGS to develop a workflow for low-cost, high-resolution HLA typing. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-15-63 DO - 10.1186/1471-2164-15-63 ID - Lange2014 ER -