Phylogeny of the PIKK family. Sequences from O. tauri (bold), H. sapiens (blue), S. cerevisiae (magenta), O. sativa (brown) and A. thaliana (green) show the grouping of five O. tauri PIKKs into conserved clades. Confidence scores labelled on the edges are bootstrap values. The distance scale is in raw score values from RaXML. Accessions for O. tauri sequences refer to the BEG gene models except where we have altered a gene model (Additional file 3: Figure S2). Sequences for A. thaliana accessions are from TAIR. Protein identification for PIKK proteins in A. thaliana are from Templeton & Moorhead . S. cerevisiae identifiers are standard names from SGD. Accessions for H. sapiens sequences are given in Additional file 9: Table S3.