Phylogeny of AGC kinases. (A) Phylogeny of the PDK1 master regulator. (B) Comparison of domain arrangement for PKA- and PKG-like kinase in H. sapiens and O. tauri. (C) Phylogeny of kinase domains for PKA- and PKG-like proteins and (D) S6K phylogeny as compared to the S. cerevisiae ortholog (SCH9) and the H. sapiens RSKs. A general explanation for phylogenies is in Figure 2. Dashed arrows (red) show distances (sum of branch lengths). The distances shown are from O. tauri kinases to their nearest orthologous sequence in each species. S. cerevisiae identifiers are standard names from SGD.