Figure 7

Schematic of GSK3 mediated signalling through the MAPK cascade in O. tauri . BSU has been shown to dephosphorylate a Y to inactivate GSK3 in plants [102], which is conserved as Y210 in GSK3. HSP90, which is conserved across eukaryotes has been shown to chaperone the autophosphorylation of the activating Y210 in GSK3 [59]. Conservation of S182 and T186 in the O. tauri MAP2K form part of a GSK3 phosphorylation motif, which when phosphorylated inhibit MAP2K activity in A. thaliana[94]. The upstream S182 is a conserved residue required for activation by MAP3K.