Figure 2

Identification of extremely highly conserved proteins using CodaChrome. (a) A segment of the CodaChrome heat map with Salmonella enterica subsp. enterica serovar Typhimurium 14028S loaded as the seed sequence and the PID threshold set at 75%. Dark pink and red columns representing pair-wise comparisons of proteins S12 and EF-Tu are indicated. (b) Enlargement of a different region of the same CodaChrome heat map as in the previous panel. PID threshold was set to 20%. The dark column on the right represents two adjacent highly conserved proteins ClpX and ClpP. The dark column on the left represents DnaK. (c) Enlargement of another region of the same CodaChrome heat map as in panel a. PID threshold is set to 20%. The region is centered on the highly conserved protein GroEL.