Impaired liver function in Xenopus tropicalis exposed to benzo[a]pyrene: transcriptomic and metabolic evidence

BMC Genomics

Table 1 Pathway enrichment study based on genes differentially transcribed between control and BaP-exposed animals

	Kegg pathway	Number of genes	Fold enrichment	p value^*
UP	Steroid biosynthesis (cholesterol biosynthesis)	7	23.8	1.6E-07
	Insulin signaling pathway	7	3.1	2.3E-02
	Adipocytokine signaling pathway	5	5	1.6E-02
	MAPK signaling pathway	9	2.5	2.4E-02
	Glycolysis / Gluconeogenesis	4	4.5	5E-02
DOWN	Steroid biosynthesis (cholesterol biosynthesis)	4	27.8	3.3E-04
	Tight junction	6	5.3	4.6E-03

The 308 genes showing a significant differential transcription at least one time point were used for annotation enrichment using the DAVID (Database for Annotation, Visualisation and Integrated Discovery) functional annotation tool. ^*modified Fisher’s Exact test (p < 0.05).

ISSN: 1471-2164