Overall effect on the transcriptome after ectopic miRNA expression. A. miRNA effects are quantitatively moderate. The fold change of expression levels for most DEGs was below 2-fold. B: Venn diagram showing common gene expression changes between cell lines. C. Heatmap showing the expression change compared to the mock samples for all down-regulated differentially expressed genes (DEGs) that are also predicted to be miR-155/miR-K12-11 targets. Most DEGs show strong tissue specificity. D. Verification of microarray measurements by qPCR on four previously reported miR-155/miR-K2-11 targets.