Figure 5

Transcription factor binding sites (TFBS) prediction for TFs directly targeted by miR-K12-11 in TIVE cells. MAPPER2 predicted thousands of genes with binding sites for each of the five TFs. A. All predicted sites with the genes not on the array, not expressed, or were not differentially expressed between miRK12-11 induction and control, or located in inactive chromatin regions according to ENCODE data in blue and the genes that are targets of TFs in red (containing seed sequences) or green. B: Genes containing TFBS and down-regulated can be further divided into two groups: those containing binding sites for both TF and miR-K12-11 (red), and those only containing TFBS but not seed sequences for miR-K12-11 (green).