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Figure 6 | BMC Genomics

Figure 6

From: A systems biology approach identified different regulatory networks targeted by KSHV miR-K12-11 in B cells and endothelial cells

Figure 6

Change of expression in the interacting genes with the five transcription factors. Among the genes that directly interact with E2F1 (A), CEBPB (B), PAX6 (C), RELA (D) and STAT1 (E), there is an enrichment of down-regulation in accordance with the center node TF genes. Protein interactions, as well as direct targeting of miR-K12-11 (genes of the circles) may contribute to the coordinated down-regulation.

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BMC Genomics

ISSN: 1471-2164

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