Figure 7

Motif enrichment analysis from DEGs of BJAB cells. Motifs identified from the promoter sequences of genes down-regulated by miR-K12-11 in BJAB cells matched the conserved binding motifs of SP1, KLF4 and MYC. SP1 and KLF4 were down-regulated themselves and may therefore relay the regulatory effect to a larger group of genes. For up-regulated genes in response to miR-K12-11, motif of FOXA1 and FOXA2 were identified as putative mediators for the increase of gene expression in BJAB cells.