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Figure 1 | BMC Genomics

Figure 1

From: Genome-wide association study combined with biological context can reveal more disease-related SNPs altering microRNA target seed sites

Figure 1

Comparisons of the SNP density between different mRNA regions grouped by global MAF. SNPs with global MAF ≥ 0.01 are defined as common SNPs, the rest are rare SNPs. The figure illustrates that the MRESS region has a significantly lower common SNP density but almost the same rare SNP density compared to the UTR regions, which indicates the MRESS region is under strong purifying selection. (Of note, the exceptionally high rare SNP density of the CDS region is derived from its unparalleled sequencing coverage).

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