Table 1 Comparison of the reported diseases between 11 validated MRESS SNPs and their corresponding interactions
SNP ID | Interaction | Reported disease of SNP | Reported disease of interaction |
|---|---|---|---|
rs1042538 | IQGAP1::hsa-miR-124 | Breast cancer* | Breast neoplasms*/prostatic neoplasms/colorectal neoplasms… |
rs1054190 | NR1I2::hsa-miR-148a | Primary sclerosing cholangitis** | Hepatocellular carcinoma**/leukemia… |
rs1056628 | MMP9::hsa-miR-491-5p | Atherosclerotic cerebral infarction* | Cerebral infarction*/multiple sclerosis… |
rs1057233 | SPI1::hsa-miR-569 | Systemic lupus erythematosus* | Systemic lupus erythematosus* |
rs1063320 | HLA-G:: hsa-miR-152 | Multiple sclerosis**/systemic lupus erythematosus/pre-eclampsia*/HCV infection | Atherosclerosis**/pre-eclampsia*/asthma… |
rs11574744 | HNF4A:: hsa-miR-34a/34c-5p | Diabetes**/renal cell carcinoma* | Metabolic diseases**/renal cell carcinoma*/coronary artery disease/alcoholic fatty liver… |
rs12720208 | FGF20:: hsa-miR-433 | Parkinson’s disease* | Parkinson’s disease*/ovarian neoplasms… |
rs1621 | MET:: hsa-miR-199a-3p | Chronic rhinosinusitis | Atrophic muscular disorders/Crohn’s disease… |
rs16917496 | SETD8:: hsa-miR-502-5p | Breast cancer/small-cell lung cancer/*epithelial ovarian cancer/*hepatocellular carcinoma | Ovarian neoplasms*/hepatocellular carcinoma* |
rs28521337 | NTRK3:: hsa-miR-485-3p | Anxiety disorders | Asthma/hepatocellular carcinoma/leukemia… |
rs5186 | AGTR1:: hsa-miR-155 | Renal disease*/hypertension*/inflammation*/pre-eclampsia*/type 2 diabetes*/mountain sickness/diastolic heart failure/*hypertrophic cardiomyopathy**/aldosterone-producing adenoma** | Renal insufficiency**/kidney diseases*/hypertension*/inflammation*/pre-eclampsia*/diabetes mellitus*/diabetes complications/heart failure*/adenocarcinoma**… |