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Figure 4 | BMC Genomics

Figure 4

From: Transcriptome instability as a molecular pan-cancer characteristic of carcinomas

Figure 4

Correlation between TIN - estimates and splicing factor expression in pooled tissue types. The left and right plots correspond to plots in Figures 2 and 3, respectively. (a) In pooled analyses of samples from four different normal tissues, the percentage of splicing factor genes (totally 280 genes; red dots) with expression levels that were significantly correlated with the TIN-estimates (P < 0.05; Pearson correlation), was not higher than expected by chance, as demonstrated by comparison with genes in each of 1,000 random sets of 280 genes (light blue) and with 1,000 permutations of the TIN-estimates (dark blue; left plot). The ratio between the amounts of significant negatively and positively correlated splicing factor genes was 2 (right plot). (b) Contrarily, across 20 randomly selected samples from each of five different cancer types with strong associations between TIN-estimates and splicing factor expression (breast cancer, cervical cancer, colorectal cancer series II, lung cancer series II, and prostate cancer I) the percentage of splicing factor genes with expression levels that were significantly correlated was higher than expected by chance (left plot). Also, there was a significant shift towards negative correlation (the ratio between the amounts of splicing factors genes with expression levels that were significant negatively and positively correlated was 17; right plot).

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