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Table 1 Quadruplex forming potential (QFP) and other structural motifs analyzed for minimum distance relationship to 5’ or 3’ human mtDNA deletion breakpoints

From: Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints

   Actual/control average distance   
   5′ breakpoints(620) 3′ breakpoints(497)   
Motif # b-p to motif Motif to b-p b-p to motif Motif to b-p Length(nt) Example
3G QFP 9 447/667 14/74*** 742/667 48/224* <33 GGG-GGG-GGG-GGG
2G QFP 178 26/36*** 79/74 23/36** 186/224* <33 GG-GG-GG-GG
SC structures 405 15/14 76/74 14/14 262/224 <100  
direct rpts. 137 44/63* 80/74 42/63* 200/224 11 ATC-ATC
inverted comp. rpts. 56 98/113 58/74 120/113 287/224 11 ATC-GAT
complementary rpts. 35 210/248 61/74 316/248 314/224 11 ATC-TAG
inverted rpts. 133 51/58 87/74 44/58 205/224 11 ATC-CTA
  1. 3G QFP and 2G QFP analyzed for breakpoints (b-p) to motif association and motif to b-p association for both 5′ and 3′ breakpoints. Actual and control distances are provided (rounded to the nearest integer). SC structure and sequence repeat predictions. At right, dashes in examples represent loops or intervening sequence. The frequency at which the control data showed a shorter average distance was tabulated to determine the p-value (* < 0.05; ** < 0.01, *** < 0.001; exact values shown in Additional file 2: Table S1). Statistically significant associations are indicated in bold.