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Table 5 Core proteins of methanogenesis

From: Comparative genomics highlights the unique biology of Methanomassiliicoccales, a Thermoplasmatales-related seventh order of methanogenic archaea that encodes pyrrolysine

Annotation "Ca.M. alvus" "Ca.M. intestinalis" M. luminyensis Distribution arCOG
Nitrogenase molybdenum-iron like protein (NifD-like/NflD) AGI86050 AGN27015 WP_019176684.1 1 arCOG04888
UDP-N-acetylmuramyl pentapeptide synthase like protein (MurF-like) AGI86051 AGN27016 WP_019176685.1 1 arCOG02822
Methyl-coenzyme M reductase operon associated like protein (McrC-like) AGI85157 AGN26013 WP_019176790.1 1 arCOG03226
Conserved hypothetical protein AGI85156 AGN26012 WP_019176789.1 1 arCOG04904
CoA-substrate-specific enzyme activase AGI85155 AGN26011 WP_019176788.1 1 arCOG02679
Conserved hypothetical protein AGI85154 AGN26010 WP_019176787.1 1 arCOG04903
Conserved hypothetical protein AGI85153 AGN26009 WP_019176786.1 1 arCOG04901
Peptidyl-prolyl cis-trans isomerase related protein AGI85152 AGN26008 WP_019176785.1 1 arCOG04900
Methyl coenzyme M reductase operon associated protein (McrC) AGI85151 AGN26006 WP_019176783.1 1 arCOG03225
Methyl-coenzyme M reductase, component A2 (AtwA) AGI85150 AGN26005 WP_019176782.1 1*† arCOG00185
Methyl coenzyme M reductase, beta subunit (McrB/MrtB) AGI85141 AGN26874 WP_019176771.1 1* arCOG04860
Methyl coenzyme M reductase, protein D (McrD/MrtD) AGI85142 AGN26873 WP_019176772.1 1* arCOG04859
Methyl coenzyme M reductase, gamma subunit (McrG/MrtG) AGI85143 AGN26872 WP_019176773.1 1* arCOG04858
Methyl coenzyme M reductase, alpha subunit (McrA/MrtA) AGI85144 AGN26871 WP_019176774.1 1* arCOG04857
SH3 fold protein AGI85145 AGN26870 WP_019176775.1 1 arCOG04846
Conserved hypothetical protein AGI85146 AGN26876 WP_019176769.1 2*† arCOG02882
AIR synthase-like protein AGI85549 AGN26462 WP_019176932.1 2 arCOG00640
Predicted DNA-binding protein containing a Zn-ribbon domain AGI84948 AGN25597 WP_019176187.1 2* arCOG01116
Methyltransferase related protein (MtxX) AGI85117 AGN26654 WP_019177314.1 3 arCOG00854
Conserved hypothetical protein AGI84870 AGN25885 WP_019178690.1 3* arCOG04893
Fe-S oxidoreductase, related to NifB/MoaA family - - - 4* arCOG00950
Conserved hypothetical protein - - - 4 arCOG04866
N5-methyltetrahydromethanopterin: coenzyme M methyltransferase, subunit A (MtrA) - - - 4* arCOG03221
N5-methyltetrahydromethanopterin: coenzyme M methyltransferase, subunit B (MtrB) - - - 4 arCOG04867
N5-methyltetrahydromethanopterin: coenzyme M methyltransferase, subunit C (MtrC) - - - 4 arCOG04868
N5-methyltetrahydromethanopterin: coenzyme M methyltransferase, subunit D (MtrD) - - - 4 arCOG04869
N5-methyltetrahydromethanopterin: coenzyme M methyltransferase, subunit E (MtrE) - - - 4 arCOG04870
Soluble P-type ATPase - - - 5 arCOG01579
Uncharacterized conserved protein - - - 5* arCOG04844
Conserved hypothetical protein (putative kinase) - - - 6 arCOG04885
  1. Protein accession numbers with the same font (bold, italics or bold-italics) are encoded by genes situated close to each other in their respective genomes.
  2. *Paralogues.
  3. †Related to a bacterial cluster with same conserved domain.
  4. 1, Methanogenesis marker, present in and unique to all sequenced methanogens and not in other archaea.
  5. 2, Present in all sequenced methanogens and less than 5% of other sequenced archaea.
  6. 3, Present in more than 90% of sequenced methanogens including Methanomassiliicoccales and less than 5% of other sequenced archaea.
  7. 4, Absent from the Methanomassiliicoccales but present and unique to all other methanogens.
  8. 5, Absent from the Methanomassiliicoccales but present in more than 90% other methanogens and not in other archaea.
  9. 6, Absent from the Methanomassiliicoccales but present in more than 90% of sequenced methanogens and less than 5% of other sequenced archaea.
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BMC Genomics

ISSN: 1471-2164

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