Hepatic transcriptomic profiling reveals early toxicological mechanisms of uranium in Atlantic salmon (Salmo salar)

Table 1 Top gene networks (score > 1, focus molecules > 1) induced in the liver of Atlantic salmon ( Salmo salar ) after 48 h waterborne exposure to 0.25, 0.5 and 1.0 mg/L nominal concentrations of depleted uranium (DU)

Top network functions	0.25 mg U/L		0.5 mg U/L		1.0 mg U/L
Top network functions	Score	DEGs	Score	DEGs	Score	DEGs
Hematological Disease, Hereditary Disorder, Tissue Morphology	181	123	181	123	181	123
Cellular Assembly and Organization, Cellular Function and Maintenance, Cell Morphology	110	89	110	89	110	89
Hereditary Disorder, Metabolic Disease, Lipid Metabolism	81	70	81	70	81	70
Developmental Disorder, Hereditary Disorder, Metabolic Disease	78	68	79	69	79	69
Endocrine System Development and Function, Small Molecule Biochemistry, Drug Metabolism	70	64	70	64	70	64
Cell Death and Survival, Cellular Movement, Tumor Morphology, Hair and Skin Development and Function	57	56	58	57	58	57
DNA Replication, Recombination, and Repair, Energy Production, Nucleic Acid Metabolism	54	54	53	53	54	54
Protein Synthesis, Gene Expression, Developmental Disorder	13	22	13	22	13	22

ISSN: 1471-2164