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Jun
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Fos and Jun dimerize to form AP-1, involved in cell proliferation, differentiation, and transformation
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Fos
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PCNA, proliferating cell nuclear antigen
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DNA synthesis, cell-cycle control, and DNA-damage response and repair
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CCND1, cyclin D1
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Regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition
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TERT1, telomerase reverse transcriptase
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Maintains telomere ends, chromosomal repair
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mycN
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Transcription factor amplified or overexpressed in variety of tumors
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cMYC
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Transcription factor activated upon various mitogenic signals such as Wnt, Shh and EGF
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gli3
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Transcription factor mediating sonic hedgehog signaling
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SOX2
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Transcription factor with roles in embryonic development, cell fate determination, stem cell maintenance
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Oct4
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Involved in the self-renewal of undifferentiated embryonic stem cells.
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Klf4
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Indicator of stem-like capacity in embryonic stem cells
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VEGF1
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Endothelial cell mitogen
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ANGPT1, angiopoietin 1
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Involved in vascular development and angiogenesis
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CAV1, caveolin
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Scaffolding protein, possible tumor suppressor
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Wnt5A
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Secreted signaling protein, activates beta catenin transcriptional activity
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Wnt11
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Secreted signaling protein, implicated in oncogenesis and in several developmental processes
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SNAI2, snail2
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Transcriptional repressor involved in epithelial-mesenchymal transitions and has antiapoptotic activity.
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TGFbeta
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Member of a family of peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types
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IGF1, insulin like growth factor
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Growth and anabolic effects
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IL2
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Cytokine regulates lymphocyte activity
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IL10
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Anti-inflammatory cytokine
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PTGS1, COX1, prostaglandin G/H synthase and cyclooxygenase)
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Converts arachidonic acid to prostaglandin
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