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Table 1 Genes included in PCR array

From: Uncovering molecular events associated with the chemosuppressive effects of flaxseed: a microarray analysis of the laying hen model of ovarian cancer

Gene Function
Jun Fos and Jun dimerize to form AP-1, involved in cell proliferation, differentiation, and transformation
Fos
PCNA, proliferating cell nuclear antigen DNA synthesis, cell-cycle control, and DNA-damage response and repair
CCND1, cyclin D1 Regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition
TERT1, telomerase reverse transcriptase Maintains telomere ends, chromosomal repair
mycN Transcription factor amplified or overexpressed in variety of tumors
cMYC Transcription factor activated upon various mitogenic signals such as Wnt, Shh and EGF
gli3 Transcription factor mediating sonic hedgehog signaling
SOX2 Transcription factor with roles in embryonic development, cell fate determination, stem cell maintenance
Oct4 Involved in the self-renewal of undifferentiated embryonic stem cells.
Klf4 Indicator of stem-like capacity in embryonic stem cells
VEGF1 Endothelial cell mitogen
ANGPT1, angiopoietin 1 Involved in vascular development and angiogenesis
CAV1, caveolin Scaffolding protein, possible tumor suppressor
Wnt5A Secreted signaling protein, activates beta catenin transcriptional activity
Wnt11 Secreted signaling protein, implicated in oncogenesis and in several developmental processes
SNAI2, snail2 Transcriptional repressor involved in epithelial-mesenchymal transitions and has antiapoptotic activity.
TGFbeta Member of a family of peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types
IGF1, insulin like growth factor Growth and anabolic effects
IL2 Cytokine regulates lymphocyte activity
IL10 Anti-inflammatory cytokine
PTGS1, COX1, prostaglandin G/H synthase and cyclooxygenase) Converts arachidonic acid to prostaglandin