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Figure 6 | BMC Genomics

Figure 6

From: Olive fly transcriptomics analysis implicates energy metabolism genes in spinosad resistance

Figure 6

STRING analysis. The network displays the predictions of protein interaction and association with experimentally determined interactions plus those from the literature of the selected gene list of up-regulated as well as down-regulated gene-products. The input gene list included the following genes: CAT-2 (CG5535), Serine protease 6 (CG2071), Yolk protein 2 (Yp2, CG2979), pNPPase (CG5567), Lsp1 (CG6821), oxidase (CG10211), MMR (CG9134), Cytochrome P450 6a23-like (Cyp6a23, CG10242), vWF domain (CG32667) and chitinase (CG9307). Network was enlarged based on Drosophila protein interactions. The ATP synthase gene (CG8189) and the Hsps were withdrawn from the list, because the resulting network was very dense and uninterpretable. Interestingly, the gene Ag5r2 (Antigen 5) even if it was also absent from the input list, it appears to be correlated with the other genes, supporting our hypothesis of interacting pathways. STRING Version 9.O was used for this analysis. Different colored edges indicate the types of evidence used in predicting the associations1. Up-regulated genes are indicated by red arrows, whereas down-regulated ones by green arrows. 1A red line indicates the presence of fusion evidence; a green line - neighborhood evidence; a blue line - coocurrence evidence; a purple line - experimental evidence; a yellow line - textmining evidence; a light blue line - database evidence; a black line - coexpression evidence.

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