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Table 2 Genes which were >3-fold up regulated in TNFα (± FSH)-treated granulosa cells compared with control (± FSH) cells

From: The global effect of follicle-stimulating hormone and tumour necrosis factor α on gene expression in cultured bovine ovarian granulosa cells

Gene symbol

Fold change

Gene symbol

Fold change

Gene symbol

Fold change

(TNFα vs non TNFα treated)

(TNFα vs non TNFα treated)

(TNFα vs non TNFα treated)

Cell death

TGM2

31

XAF1

6.8

IER3

3.6

CASP4

15.2

BCL2A1

5.3

PYCARD1

3.3

IFI6

9.2

SAMD9

4.9

TNFSF13B

3.2

BEX2

8.6

EGLN3

4.5

RIPK4

3.1

BIRC3

8.6

TRAF1

4.3

  

Cell morphology

KRT8

10

ERP27

3.5

NCK2

3.1

STMN2

7.7

PDPN

3.5

TACC1

3.1

MAP2

4.7

FMNL3

3.4

GPHN

3.0

DCLK1

4.5

MSN

3.4

MFAP2

3.0

KRT18

4.2

EMP3

3.3

  

Cytokines, hormones and receptors

GPR77

61.5

CD83

6.3

PLAUR

3.8

CD44

21.5

ROBO1

6.1

HLA-DQA1

3.7

IFI44

14.9

IFIT2

6.0

NTRK1

3.6

CD19

14.2

HLA-A

5.9

IL36A

3.6

IFI16

13.6

HLA-DQA2

5.9

EMR3

3.5

PTGER4

13.2

IL1RN

5.9

TCRA

3.5

CCL2

13.1

GPR68

5.2

TGFB1

3.5

SLCO4A1

12.3

HLA-DMB

5.0

GKN2

3.4

CD200

10.8

ICAM1

4.7

IFITM1

3.4

CXCL10

10.8

HLA-DRA

4.6

HLA-DRB3

3.3

CD40

10.1

LYVE1

4.6

FGF2

3.2

IFI27

9.5

IL1R1

4.5

VIPR2

3.2

PLXND1

9.4

NR4A2

4.3

GPR56

3.1

IFIH1

7.1

OLR1

4.0

CD72

3.1

JAG1

6.7

NRG1

3.9

IGF2

3.1

CCL5

6.4

PDGFB

3.8

  

Extracellular matrix and synthesis

TNC

52.3

COL15A1

9.4

FMOD

4.0

COL6A1

14.5

COL16A1

5.0

AGRN

3.8

LOXL4

8.8

COL5A3

4.6

FN1

3.3

Intercellular and cell to matrix adhesion

BST2

6.4

THBS3

3.6

CEACAM8

3.2

VCAM1

5.3

SPP1

3.6

CDH1

3.1

CD82

4.8

CD9

3.6

  

ITGA5

4.5

NUAK2

3.4

  

Ion transport

KCNMA1

8.9

FXYD3

3.9

CLCA3P

3.1

CACNA1G

6.9

GRIA3

3.7

SLC25A12

3.0

CNGA3

4.3

TPCN1

3.4

  

Proteolysis and inhibition

SLPI

58.6

MMP2

5.0

CTSH

3.5

UBD

17.1

PSMB10

3.9

TFPI2

3.5

SERPINB2

14.9

PSMB8

3.8

TRIM21

3.2

SERPINA5

12.5

ADAMTSL4

3.8

UBA7

3.2

ISG15

10.8

ERAP2

3.8

PRSS2

3.1

ADAM23

8.3

USP18

3.7

CFD

3.1

A2M

5.6

TIMP3

3.7

CSTB

3.1

PSMB9

5.1

C1S

3.6

  

Transcriptional regulation

GFI1

14.1

IRF1

4.7

NFKB2

3.7

NFKBIA

9.8

HEYL

4.7

NFKBIZ

3.6

FOXA3

9.0

HES4

4.6

H19

3.5

MYB

8.4

IRF8

4.2

SNAI1

3.4

MIR147

5.3

LRRFIP1

4.0

NOSTRIN

3.4

TBX3

5.2

NUPR1

4.0

DTX1

3.3

BHLHE40

4.8

RBPMS

3.9

FOXS1

3.3

TCF7

4.8

IKZF3

3.8

STAT5A

3.1

Transport

RTP4

14.5

RAB3IP

3.8

SLC37A1

3.5

ABCC3

8.0

ANKH

3.7

SLCO2A1

3.4

TF

4.1

TAP1

3.5

SYNGR1

3.1

Other enzymes

PRKCB

19.3

PNPO

5.0

TPST2

3.9

PTGIS

12.2

PIK3CD

5.0

PRKCQ

3.9

ALDH1A3

11.7

GBP4

4.8

CA5B

3.8

OAS2

10.5

MIOX

4.7

PARP14

3.7

PON3

9.3

ADCY2

4.7

PARP12

3.7

DDC

8.7

ADH6

4.5

LRAT

3.5

IDO1

7.7

UMPS

4.4

CKB

3.4

MX2

7.5

CA2

4.4

CAMK1D

3.3

HSD11B1

7.0

RSAD2

4.3

FBP1

3.3

MX1

6.6

PPP2R3C

4.3

PARP9

3.2

OAS1

5.5

BCAT2

4.3

PNKD

3.2

ABHD3

5.2

SQRDL

4.1

CA8

3.1

GLDC

5.2

ISG20

4.0

  

XDH

5.2

APOBEC3B

3.9

  

Other signalling

ENTPD3

17.7

DNER

5.8

ARHGAP24

4.8

ARHGEF5

13.6

RASAL1

5.2

DDX58

3.3

NFKB1A

9.8

TNIP1

5.5

WNT11

3.2

ARHGAP29

8.7

ARHGEF11

5.1

NKG7

3.4

ANXA8L1

8.0

ARRDC2

4.3

CDC42EP1

3.3

SLAMF8

7.4

RGS16

4.1

PDE4B

3.5

TAC3

8.7

SHISA3

4.1

IFI30

3.2

GAL

4.6

GBP5

4.0

RNF128

3.0

DAPP1

5.0

ARHGDIB

3.8

  

Other

TREM1

11.2

TMEM45B

4.6

DPY19L1

3.6

PLAC8

7.7

MS4A8B

4.6

NELL2

3.6

PARM1

6.5

SAA3

4.6

TMEM140

3.4

EPB41L3

6.3

SELENBP1

4.4

CCDC85C

3.4

FATE1

6.2

CRYBB1

4.4

OAF

3.2

TRIM47

5.4

HPCAL1

4.2

TMED6

3.2

SPARCL1

5.4

UNC13D

4.0

ABTB2

3.2

NUCB2

5.2

EPSTI1

3.9

CRIP2

3.2

PDLIM4

4.8

HSPB6

3.8

CSRP2

3.1

  1. Genes are categorised by function and listed in descending order of fold change in each category. The association of genes with functional terms in this table was determined manually for each gene based on information obtained through the Entrez Gene database of NCBI. The level of fold change and statistical significance ( ≥ 3-fold change, P < 0.05) were determined using the step up Benjamini-Hochberg post-hoc test for multiple corrections following one way ANOVA.