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Table 3 Genes which are >3-fold down regulated in TNF α (± FSH)-treated granulosa cells compared with control (± FSH) cells

From: The global effect of follicle-stimulating hormone and tumour necrosis factor α on gene expression in cultured bovine ovarian granulosa cells

Gene symbol

Fold change

Gene symbol

Fold change

Gene symbol

Fold change

(TNFα vs non TNFα treated)

(TNFα vs non TNFα treated)

(TNFα vs non TNFα treated)

Apoptosis

TRIB2

5.7

    

Cell morphology

DACT1

4.1

ACTG2

3.3

MYO1B

3.1

Cytokines, hormones and receptors

ROBO2

7.9

HEG1

5

PTN

3.5

EFNA5

7.3

PLXNC1

4.4

AMH

3.4

FST

6.2

PPARG

4.2

NR5A2

3.1

INHA

5.8

ANGPT2

3.8

KIT

3

INHBA

5.8

CD36

3.6

  

NMB

5.5

EPHA7

3.6

  

Extracellular matrix and synthesis

SPOCK2

5.0

FBLN5

4.8

EFEMP1

3.3

SRGN

5.5

    

Intercellular and cell to matrix adhesion

CYR61

5

CAV1

4.1

CTNNAL1

3.3

TSPAN5

4.9

TNFAIP6

3.5

CLDND1

3.3

NPNT

4.6

SMOC2

3.4

  

Ion transport

KCNN2

3.6

ATP4B

3.1

  

Proteolysis and inhibition

TLL2

4.8

PRSS35

3.4

SERPINE2

3.0

Transcription regulation

TOX

4.1

    

Transport

MAL2

4.0

SLC2A3

3.7

NPC1

3.0

Other enzymes

CHST8

8.4

DDAH1

4.4

PLA2G7

3.5

VNN1

6.4

HPSE

4.1

GCLC

3.4

STC1

5.8

MVK

3.7

TRIM2

3.2

PPAP2B

5.5

PDK4

3.6

  

HSD17B1

4.8

GYLTL1B

3.6

  

PTGS2

4.6

    

Other signalling

TPD52L1

7.3

DAB2

3.4

CCND2

3.1

RGS2

4.6

FGD5

3.2

SMAD2

3.1

SORBS2

4.4

RASL11B

3.2

  

RGMB

3.8

NTS

3.2

  

Other

ZNF608

4.6

EEPD1

4.4

CAPRIN2

3.5

SUSD4

4.5

LINGO2

3.7

LGALS3

3.1

  1. The level of fold change and statistical significance ( ≥ 3-fold, P < 0.05) was determined by one-way ANOVA with post-hoc Benjamini-Hochberg testing for multiple corrections. The association of genes with functional terms in this table was determined manually for each gene based on information obtained through the Entrez Gene database of NCBI. Genes are listed in descending order of fold change in each category.