Figure 4

GSEA using custom gene sets. (a) Custom gene sets representing putatively relevant processes were used for GSEA (Additional file 4: Results file S2). The FDR values were converted into enrichment scores for clustering by the formula, score = 0.1 – (0.9 *FDR). Red and green indicated up- and down- regulation, respectively. Genes in the custom sets and their sources are described in Additional file 5: Results file S3. (b) Heat-map as described in (a) for "Respiratory Disease" pathways [41] and COPD-specific pathways [42].