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Table 1 Developmentally regulated genes in whole lung from WT mice

From: Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration

Gene Name

Fold change: PND 3 vs 0

Gene Name

Fold change: PND 10 vs 3

Gene Name

Fold change: PND 42 vs 10

WT

Scnn1b-Tg

WT

Scnn1b-Tg

WT

Scnn1b-Tg

UP-REGULATED

Vaultrc5*

28.5

27.7

Clca3

71.5

12.0

Snord116*

26.2

19.6

Gm22866*

24.4

26.8

Chi3l4

12.9

4.6

Gm10722

25.7

43.9

Snora16a*

20.3

22.0

Chi3l3

10.1

5.2

Bpifa1

23.0

7.3

Rnu3a*

18.4

16.6

Crabp1

8.9

5.6

Inmt

17.8

10.8

Gm26493

17.3

13.2

Tff2

8.0

7.9

Cyp2b10

17.6

10.1

Rnu3b1*

15.7

14.7

Ltbp2

6.8

3.9

Gm10800

17.6

67.7

Gm23444

13.8

13.3

Hmcn1

5.4

3.3

Fmo3

14.9

6.6

Snord22*

13.7

13.4

C7

5.4

7.4

Lrat

14.7

14.7

Snora69*

13.3

11.9

Bpifb1

4.2

3.1

Cfd

13.9

14.4

Rny1*

13.1

15.6

Enpp1

4.0

1.9

Nr1d1

13.7

14.4

n-R5s25*

12.4

13.7

Muc5ac

4.0

1.5

C4b

13.2

13.8

Snora23*

12.4

10.5

Tnc

3.9

3.0

Gm25089*

11.8

9.5

Snord118*

11.1

7.2

A2m

3.7

2.1

Prelp

11.6

11.6

Gm24616

10.9

8.4

Muc5b

3.7

2.0

Serpina3n

11.3

6.3

Gm23927

10.0

13.5

Mir27b*

3.6

1.7

Mir680-2*

11.2

9.0

DOWN-REGULATED

Meg3*

-32.1

-34.3

Gm26493

-12.9

-16

Tnc

-25.1

-10

C530030P08Rik

-10.3

-19

Snora69*

-9.8

-9.6

Egfem1

-24

-18

Zbtb16

-8.8

-3.3

Gm24616

-8.8

-12.2

Prss35

-18.4

-9.2

Malat1*

-8.8

-9.7

Snord118*

-7.6

-4.7

Agt

-14.8

-9.3

6720401G13Rik*

-7.9

-11.7

Snora34*

-5.1

-6

Vcan

-14.4

-7.5

Mir145

-6.2

-11.9

Olfm4

-4.8

-3.9

Spon2

-12.7

-7.6

Atp6v0a4

-6.2

-2.2

Asprv1

-4.6

-1.8

Slc27a6

-12.7

-12.6

Adamtsl2

-6

-3

Cldn4

-4.5

-3.5

Frem1

-12.3

-6.4

Wnk1

-5.8

-9

Stfa3

-4.2

-3.4

Clca3

-11

11.6

Dlk1

-5.8

-4.1

H19*

-4.1

-1.5

6330403K07Rik*

-10.1

-4.8

Tead1

-5.7

-5.6

Igf2

-4

-3.1

Ccna2

-9.9

-7.8

Nfat5

-5.6

-7.6

Agtr2

-3.6

-3.2

Crabp1

-9.7

-4.8

Cox20

-5.5

-7.9

S100a14

-3.4

-3.9

Stfa2l1

-9.5

-8.7

Tfcp2l1

-5.3

-3.9

Gdpd2

-3.2

-2.6

Phex

-9.2

-5.5

Leng8

-5.2

-7.1

Smpx

-3.2

-1.3

Chi3l4

-8.9

10.5

  1. Listing of the top 15 developmentally up- and down-regulated genes from whole lung of WT mice between three separate age intervals. The fold-changes for these top 15 genes are shown for both the WT and the Scnn1b-Tg mice.
  2. * Non-coding RNA species.