Skip to main content

Table 8 Developmentally regulated Gene Ontology groups in purified macrophages from WT and Scnn1b- Tg mice

From: Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration

PND 3 vs PND 0

PND 10 vs PND 3

PND 42 vs PND 10

WT

Scnn1b-Tg

WT

Scnn1b-Tg

WT

Scnn1b-Tg

UP-REGULATED

GO:0007059 Chromosome segregation

GO:0019882 Antigen processing and presentation

NONE*

NONE*

GO:0007157 Heterophilic cell-cell adhesion

GO:0032944 Regulation of mononuclear cell proliferation

GO:0000070 Mitotic sister chromatid segregation

GO:0007059 Chromosome segregation

  

NONE*

GO:0070663 Regulation of leukocyte proliferation

GO:0000819 Sister chromatid segregation

GO:0048002 Antigen processing and presentation of peptide antigen

   

GO:0050670 Regulation of lymphocyte proliferation

GO:0006310 DNA recombination

GO:0071346 Cellular response to interferon-gamma

   

GO:0045058 T cell selection

GO:0006302 Double-strand break repair

GO:0032615 Interleukin-12 production

   

GO:0050870 Positive regulation of T cell activation

GO:0007067 Mitosis

GO:0032655 Regulation of interleukin-12 production

   

GO:0042129 Regulation of T cell proliferation

GO:0006281 DNA repair

GO:0045087 Innate immune response

   

GO:0006720 Isoprenoid metabolic process

GO:0048285 Organelle fission

GO:0002474 Antigen processing and presentation of peptide antigen via MHC class I

   

GO:0051251 Positive regulation of lymphocyte activation

GO:0000280 Nuclear division

GO:0032606 Type I interferon production

   

GO:0048002 Antigen processing and presentation of peptide antigen

GO:0000725 Recombinational repair

GO:0032479 Regulation of type I interferon production

   

GO:0070661 Leukocyte proliferation

DOWN-REGULATED

GO:0060541 Respiratory system development

GO:0060485 Mesenchyme development

GO:0035456 Response to interferon-beta

GO:0030595 Leukocyte chemotaxis

GO:0007059 Chromosome segregation

GO:0007067 Mitosis

GO:0030324 Lung development

GO:0030324 Lung development

GO:0035458 Cellular response to interferon-beta

GO:0050900 Leukocyte migration

GO:0007067 Mitosis

GO:0000280 Nuclear division

GO:0030323 Respiratory tube development

GO0030323 Respiratory tube development

GO:0045087 Innate immune response

GO:0045087 Innate immune response

GO:0000280 Nuclear division

GO:0007059 Chromosome segregation

GO:0060485 Mesenchyme development

GO:0060541 Respiratory system development

GO:0045851 pH reduction

GO:0006954 Inflammatory response

GO:0048285 Organelle fission

GO:0048285 Organelle fission

GO:0002009 Morphogenesis of an epithelium

GO:0001657 Ureteric bud development

GO:0051607 Defense response to virus

GO:0006955 Immune response

GO:0000070 Mitotic sister chromatid segregation

GO:0000819 Sister chromatid segregation

GO:0048762 Mesenchymal cell differentiation

GO:0055123 Digestive system development

GO:0051453 Regulation of intracellular pH

GO:0060326 Cell chemotaxis

GO:0000819 Sister chromatid segregation

GO:0033700 Phospholipid efflux

GO:0048729 Tissue morphogenesis

GO:0048762 Mesenchymal cell differentiation

GO:0051452 Intracellular pH reduction

GO:0048520 Positive regulation of behavior

GO:0000278 Mitotic cell cycle

GO:0000070 Mitotic sister chromatid segregation

GO:0003007 Heart morphogenesis

GO:0048562 Embryonic organ morphogenesis

GO:0048525 Negative regulation of viral process

GO:0032103 Positive regulation of response to external stimulus

GO:0000725 Recombinational repair

GO:0007052 Mitotic spindle organization

GO:0048562 Embryonic organ morphogenesis

GO:0048565 Digestive tract development

GO:0030641 Regulation of cellular pH

GO:0002690 Positive regulation of leukocyte chemotaxis

GO:0007052 Mitotic spindle organization

GO:0070301 Cellular response to hydrogen peroxide

GO:0010632 Regulation of epithelial cell migration

GO:2000736 Regulation of stem cell differentiation

GO:0002224 Toll-like receptor signaling pathway

GO:0002687 Positive regulation of leukocyte migration

GO:0000724 Double-strand break repair via homologous recombination

GO:0090068 Positive regulation of cell cycle process

  1. Top ten developmentally up- and down-regulated Gene Ontology groups for purified macrophages in WT and Scnn1b-Tg mice between the specified developmental intervals. Gene Ontology groups in common between the WT and Scnn1b-Tg line are highlighted by bolded and italicized text. Groups are only listed if FDR <0.1.
  2. *NONE indicates that no groups met the significance threshold (FDR<0.1).